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J Korean Med Sci. 2017 Aug;32(8):1268-1274. doi: 10.3346/jkms.2017.32.8.1268.

Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study.

Author information

1
Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
2
Division of Infectious Disease, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
3
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
4
Department of Infectious Diseases, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
5
Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
6
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
7
Institute for Health and Society, Hanyang University, Seoul, Korea.
8
Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
9
Division of AIDS, Korea Centers for Disease Control and Prevention, Osong, Korea.
10
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
11
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. seran@yuhs.ac.

Abstract

Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m², and 16.4% of the patients had a BMI over 25 kg/m². A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.

KEYWORDS:

Dyslipidemia; HIV Infection; Metabolic Complication; Protease Inhibitor

PMID:
28665062
PMCID:
PMC5494325
DOI:
10.3346/jkms.2017.32.8.1268
[Indexed for MEDLINE]
Free PMC Article

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