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Proteomics. 2017 Dec;17(23-24). doi: 10.1002/pmic.201600431. Epub 2017 Oct 12.

Autotransporter Adhesins in Escherichia coli Pathogenesis.

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Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.


Most bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An important group of bacterial adhesins belong to the autotransporter (AT) superfamily, the largest group of secreted and outer membrane proteins in Gram-negative bacteria. AT adhesins possess diverse functions that facilitate bacterial colonisation, survival and persistence, and as such are often associated with increased bacterial fitness and pathogenic potential. In this review, we will describe AIDA-I type AT adhesins, which comprise the biggest and most diverse group in the AT family. We will focus on Escherichia coli proteins and define general aspects of their biogenesis, distribution, structural properties and key roles in infection.


autotransporter adhesins; bacterial aggregation; bacterial pathogenesis; biofilm formation factor; type V secretion system

[Indexed for MEDLINE]

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