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eNeuro. 2017 Jun 28;4(3). pii: ENEURO.0111-17.2017. doi: 10.1523/ENEURO.0111-17.2017. eCollection 2017 May-Jun.

The Virtual Mouse Brain: A Computational Neuroinformatics Platform to Study Whole Mouse Brain Dynamics.

Author information

1
Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.

Abstract

Connectome-based modeling of large-scale brain network dynamics enables causal in silico interrogation of the brain's structure-function relationship, necessitating the close integration of diverse neuroinformatics fields. Here we extend the open-source simulation software The Virtual Brain (TVB) to whole mouse brain network modeling based on individual diffusion magnetic resonance imaging (dMRI)-based or tracer-based detailed mouse connectomes. We provide practical examples on how to use The Virtual Mouse Brain (TVMB) to simulate brain activity, such as seizure propagation and the switching behavior of the resting state dynamics in health and disease. TVMB enables theoretically driven experimental planning and ways to test predictions in the numerous strains of mice available to study brain function in normal and pathological conditions.

KEYWORDS:

connectome; fMRI; modeling; resting state

PMID:
28664183
PMCID:
PMC5489253
DOI:
10.1523/ENEURO.0111-17.2017
[Indexed for MEDLINE]
Free PMC Article

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