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Integr Med Res. 2014 Dec;3(4):172-179. doi: 10.1016/j.imr.2014.09.007. Epub 2014 Oct 5.

Exercise-induced myokines in health and metabolic diseases.

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Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, Korea.
Institute on Aging, Seoul National University, Seoul, Korea.


Skeletal muscle has been emerging as a research field since the past 2 decades. Contraction of a muscle, which acts as a secretory organ, stimulates production, secretion, and expression of cytokines or other muscle fiber-derived peptides, i.e., myokines. Exercise-induced myokines influence crosstalk between different organs in an autocrine, endocrine, or paracrine fashion. Myokines are recently recognized as potential candidates for treating metabolic diseases through their ability to stimulate AMP-activated protein kinase signaling, increase glucose uptake, and improve lipolysis. Myokines may have positive effects on metabolic disorders, type 2 diabetes, or obesity. Numerous studies on myokines suggested that myokines offer a potential treatment option for preventing metabolic diseases. This review summarizes the current understanding of the positive effects of exercise-induced myokines, such as interleukin-15, brain-derived neurotrophic factor, leukemia inhibitory factor, irisin, fibroblast growth factor 21, and secreted protein acidic and rich in cysteine, on metabolic diseases.


exercise; health; metabolic diseases; myokines

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