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J Nat Prod. 2017 Jul 28;80(7):1964-1971. doi: 10.1021/acs.jnatprod.6b00951. Epub 2017 Jun 29.

Curcumin Acrylation for Biological and Environmental Applications.

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Department of Chemical and Materials Engineering, University of Kentucky , Lexington, Kentucky 40506, United States.
Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky , Lexington, Kentucky 40536, United States.


Curcumin has recently gained interest for use in drug delivery, chemical sensing, and environmental applications. As a result, the development of synthesis strategies for the incorporation of curcumin into novel materials has become a priority. One such strategy, curcumin acrylation, involves the introduction of acrylate functional groups to the curcumin scaffold, with the potential generation of mono-, di-, and triacrylate curcumin species. The relative populations of these species in the resulting multiacrylate mixture can be controlled by the ratio of curcumin to acryloyl chloride in the initial reaction formulation. Characterization of the acrylation reaction and the resulting curcumin multiacrylate product is essential for the effective preparation of new curcumin-containing materials. In this work, a synthesis method for curcumin acrylation is presented and the resulting curcumin multiacrylate product is characterized via various techniques, i.e., HPLC, LCMS, and NMR, as a basis to establish the relationship between synthesis conditions and the extent of acrylation that is achieved.

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