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Front Pharmacol. 2017 Jun 13;8:300. doi: 10.3389/fphar.2017.00300. eCollection 2017.

Exosomes: A Novel Strategy for Treatment and Prevention of Diseases.

Wang J1,2, Sun X1,2, Zhao J1, Yang Y1,2, Cai X1,2, Xu J3, Cao P1,2.

Author information

1
Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineNanjing, China.
2
Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical SciencesNanjing, China.
3
Department of Endoscopy, Quzhou People's HospitalQuzhou, China.

Abstract

An "exosome" is a nanoscale membrane vesicle derived from cell endocytosis that functions as an important intercellular communication mediator regulating the exchange of proteins and genetic materials between donor and surrounding cells. Exosomes secreted by normal and cancer cells participate in tumor initiation, progression, invasion, and metastasis. Furthermore, immune cells and cancer cells exert a two-way bidirectional regulatory effect on tumor immunity by exchanging exosomes. Current studies on exosomes have further expanded their known functions in physiological and pathological processes. The purpose of this review is to describe their discovery and biological functions in the context of their enormous potential in the clinical diagnosis, prevention, and treatment of cancer as well as bacterial and viral infectious diseases.

KEYWORDS:

cancer; diagnosis index; drug delivery; exosomes; pathogenic microorganism; vesicles

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