Format

Send to

Choose Destination
Food Nutr Res. 2017 Jun 1;61(1):1333390. doi: 10.1080/16546628.2017.1333390. eCollection 2017.

Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage.

Liu L1,2,3, Wu X2, Zhang B1,3, Yang W2, Li D1,3, Dong Y1,3, Yin Y2, Chen Q1,3,4.

Author information

1
Fujian Key Laboratory of Innate Immune Biology, Fuzhou, Fujian, China.
2
School of Physical Education and Sport Science, Fujian Normal University, Fuzhou, China.
3
Biomedical Research Center of South China, Fujian Normal University, Fuzhou, China.
4
College of Life Science, Fujian Normal University, Fuzhou, China.

Abstract

Background: The beneficial properties of tea polyphenols have been extensively studied; however, less attention has been paid to their effects, especially anti-inflammatory effect during exhaustive exercise. Objective: The present study assessed the potential protective effects of tea polyphenols against the fatigue, inflammation and tissue injury caused by an exhaustive exercise bout in rats. Design: Twenty-four healthy male rats were divided into three groups. Group C was a sedentary control group, Groups E+TP and Group E performed a single exhaustive swimming test; all groups had normal diets, but Group E+TP was supplemented with tea polyphenols. All rats were immediately euthanized after exhaustive exercise, and biochemical and inflammatory parameters, including lactic acid (LA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), lactic dehydrogenase (LDH), and creatine kinase (CK) activity levels, were measured. Reverse transcription (RT) and Real-Time PCR was employed to evaluate the mRNA expression of IL-1β in the liver. Results: The results showed a decrease in serum LA levels (22%, p < 0.05) in rats that consumed dietary tea polyphenols. Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-α: 13%, p < 0.05; IL-1β: 10%, p < 0.05; and IL-6: 48%, p < 0.05) and shifted the serum IL-10/TNF-α ratio to a predominantly anti-inflammatory milieu (0.52 ± 0.07 vs. 0.67 ± 0.10, p < 0.01). Furthermore, the polyphenols effectively inhibited the release of tissue damage markers (CK: 24%, p < 0.05 and LDH: 28%, p < 0.05) in the serum and decreased IL-1β mRNA expression in the liver. Conclusions: This study indicated that tea polyphenols could significantly protect rats from the fatigue, inflammation and tissue damage induced by acute exhaustive exercise.

KEYWORDS:

Green tea; anti-inflammatory effects; lactic acid; mRNA expression; pro-inflammatory factors

Supplemental Content

Full text links

Icon for Swedish Nutrition Foundation Icon for PubMed Central
Loading ...
Support Center