Send to

Choose Destination
J Clin Diagn Res. 2017 May;11(5):IE01-IE05. doi: 10.7860/JCDR/2017/23927.9886. Epub 2017 May 1.

The Impact of Oxidative Stress on Testicular Function and the Role of Antioxidants in Improving it: A Review.

Author information

Student Research Committee of Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran: Biotechnology laboratory of ASRI, Karaj, Iran.
Leishmaniasis Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Razi Herbal Medicines Research center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.


Oxidative stress is an important factor for development of male infertility because of very high rate of cell division and mitochondrial oxygen consumption in testicular tissue as well as comparably higher levels of unsaturated fatty acids in this tissue than in other tissues. Moreover, the level of oxygen pressure is low due to the weakness of testicular artery; therefore, there is a severe cell competition for oxygen. Therefore, the testicular tissue and male reproductive system are particularly susceptible to oxidative stress. On the other hand, exposure to X-ray, toxins and chemicals found in the environment as well as specific physical conditions such as varicocele can exacerbate the oxidative stress and induce apoptosis of germ cells and subsequently spermatogenesis. However, under normal conditions, the body's capacity to produce antioxidants for inhibiting adverse effects of oxidative stress is affected by metabolic process and genetic structure. Besides that, environmental factors such as diet, pollutants, and chemicals can affect this capacity. Thus, the body's antioxidant system alone is not able to neutralize all free radicals and prevent harmful complications of oxidative stress. Therefore, use of antioxidants and development of antioxidant therapy can break down the oxidative chain reaction and play a very significant role in increasing the body's capacity to fight free radical-induced oxidative stress, and therefore improve the process of spermatogenesis.


Medicinal plants; Testice; Traditinal medicine

[Available on 2017-07-01]

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center