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Virulence. 2017 Nov 17;8(8):1643-1656. doi: 10.1080/21505594.2017.1346756. Epub 2017 Jul 31.

Dectin-1 plays an important role in host defense against systemic Candida glabrata infection.

Author information

1
a Shanghai Tenth People's Hospital, and Department of Pharmacology , Tongji University School of Medicine , Shanghai , P.R. China.
2
b Department of Laboratory Medicine , Shanghai East Hospital, Tongji University School of Medicine , Shanghai , P.R. China.
3
c Department of Dermatology , Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai , P.R. China.
4
d R&D Center of New Drug, School of Pharmacy, Second Military Medical University , Shanghai , P.R. China.

Abstract

Candida glabrata is the second most common pathogen of severe candidiasis in immunocompromised hosts, following C. albicans. Although C. glabrata and C. albicans belong to the same genus, they are phylogenetically distinct. C-type lectin receptors (CLRs), acting as pattern-recognition receptors (PRRs), play critical roles in host defense against C. albicans infections. However, our understanding of the specific roles of CLRs in host defense against C. glabrata is limited. Here, we explored the potential roles of the C-type lectins Dectin-1 and Dectin-2 in host defense against C. glabrata. We found that both Dectin-1-deficient mice (Dectin-1-/-) and Dectin-2-deficient mice (Dectin-2-/-) are more susceptible to C. glabrata infection. Dectin-1confers host higher sensitivity for sensing C. glabrata infections, while the effect of Dectin-2 in the host defense against C. glabrata is infection dose dependent. Dectin-1 is required for host myeloid cells recognition, killing of C. glabrata, and development of subsequent Th1 and Th17 cell-mediated adaptive immune response. Significantly impaired inflammatory responses such as inflammatory cells recruitment and cytokines release that were induced by C. glabrata were manifested in Dectin-1-deficient mice. Together, our study demonstrates that Dectin-1 plays an important role in host defense against systemic Candida glabrata infections, indicating a previous unknown control mechanism for this particular type of infection in host. Our study, therefore, provides new insights into the host defense against C. glabrata.

KEYWORDS:

Candida glabrata; Dectin-1; Dectin-2; immune response; invasive fungal infections

Comment in

PMID:
28658592
PMCID:
PMC5810470
DOI:
10.1080/21505594.2017.1346756
[Indexed for MEDLINE]
Free PMC Article

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