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Arq Neuropsiquiatr. 2017 Jun;75(6):381-386. doi: 10.1590/0004-282X20170066.

Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies.

Author information

1
Hospital Barão de Lucena, Recife PE, Brasil.
2
Associação de Assistência à Criança Deficiente (AACD), Recife PE, Brasil.
3
Centro de Reabilitação Dr. Henrique Santillo, Goiania GO, Brasil.
4
Universidade Federal de Pernambuco, Recife PE, Brasil.
5
Hospital Agamenon Magalhães, Recife PE, Brasil.
6
Instituto de Medicina Integral Professor Fernando Figueira, Recife PE, Brasil.
7
Centro Diagnóstico Multimagem, Recife PE, Brasil.
8
Universidade Mauricio de Nassau, Recife PE, Brasil.
9
Universidade de Pernambuco, Recife PE, Brasil.
10
Fundação Altino Ventura, Recife PE, Brasil.
11
Hospital de Olhos de Pernambuco (HOPE), Recife PE, Brasil.
12
UniVision, Recife PE, Brasil.
13
Centro de Pesquisas Aggeu Magalhães-Fiocruz, Recife PE, Brasil.
14
Hospital Universitário Oswaldo Cruz, Recife PE, Brasil.

Abstract

Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.

PMID:
28658408
DOI:
10.1590/0004-282X20170066
[Indexed for MEDLINE]
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