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Medicine (Baltimore). 2017 Jun;96(26):e7065. doi: 10.1097/MD.0000000000007065.

Menopausal status and the risk of lung cancer in women: A PRISMA-compliant meta-analysis.

Author information

1
aDepartment of Respiration, Clinical Medical School of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou bDepartment of Urology, Taizhou People's Hospital, Taizhou, Jiangsu, China.

Abstract

BACKGROUND:

Quantification of the association between menopausal status and risk of lung cancer is inconsistent. We carried out a meta-analysis of available studies to examine this issue.

METHODS:

Relevant articles were identified by searching PudMed and Embase databases. Reference lists from selected papers were also reviewed. A random-effect model was used to calculate summary odds ratios (OR) and relative risk (RR) with 95% confidence interval (CI). Publication bias was estimated using Egger regression asymmetry test.

RESULTS:

Eight eligible studies, including 5 case-control studies and 3 cohort studies, provided data for meta-analysis. Postmenopausal women had a statistically significant increased risk of lung cancer in all included studies (RR = 1.44, 95% CI: 1.12-1.85) and cohort studies (RR = 1.39, 95% CI: 1.05-1.86), but not in case-control studies (OR = 1.46, 95% CI: 0.95-2.24).

CONCLUSIONS:

Overall, there was evidence that postmenopause is related to increased lung cancer risk. However, studies have produced slightly heterogeneous results (I = 38.40%). To obtain a better indication of relationship, well-designed large prospective studies are required.

PMID:
28658099
PMCID:
PMC5500021
DOI:
10.1097/MD.0000000000007065
[Indexed for MEDLINE]
Free PMC Article

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