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J Physiol Sci. 2017 Sep;67(5):549-560. doi: 10.1007/s12576-017-0552-x. Epub 2017 Jun 27.

Involvement of thermosensitive TRP channels in energy metabolism.

Author information

1
Division of Cell Signaling, Okazaki Institute for Integrative Biosciences (National Institute for Physiological Sciences), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan. uchida@college.fdcnet.ac.jp.
2
Department of Physiological Sciences, SOKENDAI (The University of Advanced Studies), 38 Nishigounaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan. uchida@college.fdcnet.ac.jp.
3
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka, Fukuoka, 814-0193, Japan. uchida@college.fdcnet.ac.jp.
4
Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 320-0498, Japan.
5
Diabetes Center, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA, 94143-0669, USA.
6
Faculty of Future Industry, Happy Science University, 4427-1 Hitotsumatsu-hei, Chosei-mura, Chiba, 299-4325, Japan.
7
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka, Fukuoka, 814-0193, Japan.
8
Hokkaido University, Kita18-Nishi9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan.
9
Division of Cell Signaling, Okazaki Institute for Integrative Biosciences (National Institute for Physiological Sciences), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan.
10
Department of Physiological Sciences, SOKENDAI (The University of Advanced Studies), 38 Nishigounaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan.
11
Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 320-0498, Japan. ysk-iwasaki@jichi.ac.jp.

Abstract

To date, 11 thermosensitive transient receptor potential (thermo-TRP) channels have been identified. Recent studies have characterized the mechanism of thermosensing by thermo-TRPs and the physiological role of thermo-TRPs in energy metabolism. In this review, we highlight the role of various thermo-TRPs in energy metabolism and hormone secretion. In the pancreas, TRPM2 and other TRPs regulate insulin secretion. TRPV2 expressed in brown adipocytes contributes to differentiation and/or thermogenesis. Sensory nerves that express TRPV1 promote increased energy expenditure by activating sympathetic nerves and adrenaline secretion. Here, we first show that capsaicin-induced adrenaline secretion is completely impaired in TRPV1 knockout mice. The thermogenic effects of TRPV1 agonists are attributable to brown adipose tissue (BAT) activation in mice and humans. Moreover, TRPA1- and TRPM8-expressing sensory nerves also contribute to potentiation of BAT thermogenesis and energy expenditure in mice. Together, thermo-TRPs are promising targets for combating obesity and metabolic disorders.

KEYWORDS:

Adrenaline; Brown adipose adipocyte; Energy expenditure; Insulin; TRP channel; UCP1

PMID:
28656459
DOI:
10.1007/s12576-017-0552-x
[Indexed for MEDLINE]

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