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Neurol Sci. 2017 Dec;38(12):2199-2201. doi: 10.1007/s10072-017-3028-0. Epub 2017 Jun 27.

Acute toxic leukoencephalopathy associated with a non-prescription weight loss supplement: a report of two cases.

Author information

1
Instituto de Neurología y Neurocirugía, Centro Medico Zambrano Hellion, Tecnológico de Monterrey, Ave Batallón de San Patricio # 112, Colonia Real de San Agustín, 66278, San Pedro Garza García, N.L., Mexico.
2
Servicio de Neurología, Hospital Universitario UANL, Monterrey, Mexico.
3
Instituto de Neurología y Neurocirugía, Centro Medico Zambrano Hellion, Tecnológico de Monterrey, Ave Batallón de San Patricio # 112, Colonia Real de San Agustín, 66278, San Pedro Garza García, N.L., Mexico. drhectormtz@yahoo.com.
4
Servicio de Neurología, Hospital Universitario UANL, Monterrey, Mexico. drhectormtz@yahoo.com.

Abstract

Weight loss dietary supplements are used with some frequency by an increasingly overweight population. Some products are not adequately regulated and may pose potential health risks. We report two new cases of acute toxic leukoencephalopathy (ATL) due to the use of a supplement marketed as a thermogenic weight loss aid. ATL is a heterogeneous clinic-radiological entity that has been associated with various compounds, such as chemotherapeutic drugs and immunomodulators. It is characterized by an often reversible periventricular and infratentorial demyelination. The commercialization of non-regulated weight loss products continues to be a health risk in our population.

KEYWORDS:

Dietary supplements; Leukoencephalopathy; MRI; Toxic leukoencephalopathy; White matter

PMID:
28656377
DOI:
10.1007/s10072-017-3028-0
[Indexed for MEDLINE]

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