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Hum Pathol. 2017 Aug;66:222-229. doi: 10.1016/j.humpath.2017.06.008. Epub 2017 Jun 24.

High tumor budding count is associated with adverse clinicopathologic features and poor prognosis in breast carcinoma.

Author information

1
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322. Electronic address: xli40@emory.edu.
2
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322. Electronic address: bo.wei@emory.edu.
3
Department of Biology, Georgia State University, Atlanta, GA 30302. Electronic address: ceyda.sonmez@gmail.com.
4
Department of Pathology, The Ohio State University, Columbus, OH 43210. Electronic address: zaibo.li@osumc.edu.
5
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322. Electronic address: lpeng@emory.edu.

Abstract

This study is to address the significance of tumor budding (TB) in breast carcinoma. Totally 244 estrogen receptor-positive (ER+)/HER2-negative (HER2-) and 131 triple-negative breast carcinoma (TNBC) diagnosed from 2004 to 2014 were analyzed. TB (cluster of up to 5 tumor cells at the invasive front) was evaluated using five 200× high-power fields (HPF) at the hotspot. The highest TB (H-TB) in 1 HPF and average TB (A-TB) in 5 HPFs were correlated with lymph node and distant metastasis, lymphovascular invasion (LVI), local recurrence, overall survival (OS), and disease-free survival (DFS). In ER+/HER2- cancer, H-TB and A-TB were significantly associated with distant metastasis. In TNBC, H-TB was associated with distant metastasis by univariate but not multivariate analysis; H-TB and A-TB were associated with LVI and worse OS (all P < .05). TB is associated with poor prognosis in ER+/HER2- and TNBC cancer. Evaluation of H-TB may be sufficient in breast carcinoma.

KEYWORDS:

Breast cancer; Disease-free survival; ER+ breast cancer; Metastasis; Overall survival; TNBC; Tumor budding

PMID:
28655638
DOI:
10.1016/j.humpath.2017.06.008
[Indexed for MEDLINE]

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