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Toxicol Lett. 2017 Aug 5;277:104-108. doi: 10.1016/j.toxlet.2017.06.008. Epub 2017 Jun 24.

Safety assessment of green tea based beverages and dried green tea extracts as nutritional supplements.

Author information

1
Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany. Electronic address: dekant@toxi.uni-wuerzburg.de.
2
R&D, Safety Science Research, Kao Corporation, 2606 Akabane Ichikai-Machi Haga-Gun, 321-3497 Tochigi, Japan.
3
R&D, Health Care Food Research, Kao Corporation, 2-1-3 Bunka Sumida-ku, 131-8501 Tokyo, Japan.

Abstract

The safety of green tea infusions and green tea extract (GTE)-based products is reviewed regarding catechins. Epigallocatechin 3-gallate (EGCG), the major catechin present in green tea, is suspected of being responsible for liver toxicity reported in humans consuming food supplements. Intake of EGCG with green tea infusions and GTE-based beverages is up to about 450mg EGCG/person/day in Europe and higher in Asia. Consumption of green tea is not associated with liver damage in humans, and green tea infusion and GTE-based beverages are considered safe in the range of historical uses. In animal studies, EGCG's potency for liver effects is highly dependent on conditions of administration. Use of NOAELs from bolus administration to derive a tolerable upper intake level applying the margin of safety concept results in acceptable EGCG-doses lower than those from one cup of green tea. NOAELs from toxicity studies applying EGCG with diet/split of the daily dose are a better point of departure for risk characterization. In clinical intervention studies, liver effects were not observed after intakes below 600mg EGCG/person/day. Thus, a tolerable upper intake level of 300mg EGCG/person/day is proposed for food supplements; this gives a twofold safety margin to clinical studies that did not report liver effects and a margin of safety of 100 to the NOAELs in animal studies with dietary administration of green tea catechins.

KEYWORDS:

Catechins; Food supplements; Green tea; Safety assessment

PMID:
28655517
DOI:
10.1016/j.toxlet.2017.06.008
[Indexed for MEDLINE]

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