Format

Send to

Choose Destination
J Clin Gastroenterol. 2018 Aug;52(7):635-640. doi: 10.1097/MCG.0000000000000817.

Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn's Disease.

Author information

1
Department of Surgery.
2
Institute of Pathology.
3
Department of Internal Medicine III, Medical Faculty Mannheim, Heidelberg University, Germany.
4
Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ).
5
Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
6
Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.

Abstract

GOALS:

The aim of this study was to assess the histopathologic characteristics of colorectal carcinomas (CRC) in patients with Crohn's disease (CD).

BACKGROUND:

A higher frequency of microsatellite instability (MSI) is seen in mucinous compared with nonmucinous CRC which suggests that its pathogenesis involves distinct molecular pathways. Several publications reported a higher percentage of mucinous adenocarcinoma in CD patients with CRC. So far, there has been no investigation of MSI in CD patients with mucinous CRC.

STUDY:

The medical records of patients who underwent surgery for CRC were reviewed and those with a history of CD identified. The data of histologic classification and MSI status of the tumor were investigated.

RESULTS:

Fourteen patients with CD-associated CRC were identified (5 female, 9 male) resulting in 20 CRC in total. Histologic investigation revealed 7 adenocarcinomas without a mucinous or signet ring cell component. All other CRCs harbored a mucinous (n=11) and/or signet ring cell (n=6) component. All tumors assessed for MSI were found to be microsatellite stable.

CONCLUSIONS:

Our data indicate that CRCs with signet ring cell and mucinous components were much more common in patients with CD than in patients with sporadic CRC. This observation suggests that CRC in CD represent an own entity with distinct histopathologic and molecular features. This may implicate potential consequences for diagnosis and therapy of CRC in CD in the future as well as new factors to identify patients with an increased risk for developing CRC in CD.

PMID:
28654553
DOI:
10.1097/MCG.0000000000000817
Free full text

Supplemental Content

Full text links

Icon for Wolters Kluwer Icon for Zurich Open Access Repository and Archive
Loading ...
Support Center