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J Nat Prod. 2017 Jul 28;80(7):2037-2044. doi: 10.1021/acs.jnatprod.7b00170. Epub 2017 Jun 27.

Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species.

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Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.
Natural Products Discovery Institute , Doylestown, Pennsylvania 18902, United States.
Department of Chemistry and Biochemistry, Natural Products Discovery Group, and Institute for Natural Products Applications and Research Technologies, University of Oklahoma , Norman, Oklahoma 73019-5251, United States.


Bioassay-guided fractionation of a colon cancer growth inhibitory extract of the fungus Paraconiothyrium sp. led to the isolation of eight new versiol derivatives (1, 3-8, 10) along with two known compounds. The structures were elucidated by interpretation of combined MS and 2D NMR spectroscopic data. Compounds 8, 9, and 10 showed cell growth inhibition against COLO205 and KM12 cells, and both 8 and 9 displayed selectivity in their inhibition of melanoma cell lines in the NCI 60 one-dose test. In addition, compound 8 and the crude Paraconiothyrium sp. extract showed potent dose-dependent inhibitory effects in the five-dose NCI 60 cell line assay.

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