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J Clin Lab Anal. 2018 Mar;32(3). doi: 10.1002/jcla.22291. Epub 2017 Jun 27.

Serum carcinoembryonic antigen is positively associated with leukocyte count in Korean adults.

Author information

1
Department of Family Medicine, Yong-in Severance Hospital, Yonsei University College of Medicine, Yong-in, Korea.
2
Department of Medicine, Gradauate School of Yonsei University College of Medicine, Seoul, Korea.
3
Biostatistics Collaboration Units, Department of Research Affairs, Yonsei University College of Medicine, Seoul, Korea.
4
Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
5
Department of Family Medicine, Gangam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND:

Emerging evidence shows that serum carcinoembryonic antigen (CEA) levels may modestly be increased in non-neoplastic conditions such as cardiometabolic diseases, which are increasingly being seen as inflammatory diseases. Leukocyte count is widely evaluated marker of inflammation in clinical practice and a useful predictor of cardiometabolic disease. In this study, we aimed to determine the relationship between serum CEA levels and leukocyte counts in Korean adults.

METHODS:

This cross-sectional study included a total of 19 834 individuals enrolled from a health promotion center between November 2006 and July 2010. Multiple linear regression analysis was performed to investigate the association between serum CEA levels and leukocyte counts after adjusting for confounding variables.

RESULTS:

According to both stepwise-method and enter-method multiple linear regression analyses, serum CEA levels were positively and independently associated with leukocyte counts (P<.001) after adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, HDL-cholesterol, cigarette smoking, alcohol ingestion, physical activity, diabetes mellitus, and anti-inflammatory drugs.

CONCLUSIONS:

We demonstrate a positive relationship between serum CEA levels and leukocyte counts in Korean adults. Our results suggested that an elevated serum CEA level may reflect chronic inflammation state.

KEYWORDS:

carcinoembryonic antigen; leukocyte count; subclinical inflammation

PMID:
28653772
DOI:
10.1002/jcla.22291
[Indexed for MEDLINE]

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