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Genet Mol Res. 2017 Jun 20;16(2). doi: 10.4238/gmr16029617.

Clinical significance of fascin-1 and laminin-5 in non-small cell lung cancer.

Author information

1
Department of Thoracic Surgery, Beijing Chest Hospital, , , China.
2
Department of Cellular and Molecular Biology, Beijing Chest Hospital, , , China.
3
Department of Thoracic Surgery, Beijing Chest Hospital, , , China wztdoctor@163.com.

Abstract

Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC) were analyzed in this study. The expression of fascin-1 and laminin-5 were examined in 378 patients and their serum level was measured in 154 patients. The health of all patients was followed post-surgery. The expression of fascin-1 (P = 0.000) and lanminin-5 (P = 0.001) and the serum levels of fascin-1 (P = 0.015) and laminin-5 (P = 0.046) were related to the relapse of patients with NSCLC. Both serum levels and expression of fascin-1 and laminin-5 can be used to effectively evaluate the prognoses of patients with NSCLC.

PMID:
28653739
DOI:
10.4238/gmr16029617
[Indexed for MEDLINE]

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