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J Neurooncol. 2017 Sep;134(2):339-347. doi: 10.1007/s11060-017-2531-8. Epub 2017 Jun 26.

The clinical features and surgical outcomes of intracranial tanycytic ependymomas: a single-institutional experience.

Tao X1, Dong J1, Hou Z1, Hao S1, Zhang Q2, Wu Z1, Zhang J1, Liu B3,4,5,6,7.

Author information

1
Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing, 100050, People's Republic of China.
2
Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
3
Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing, 100050, People's Republic of China. liubaiyun1963@163.com.
4
Department of Neurotrauma, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China. liubaiyun1963@163.com.
5
Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, 100050, China. liubaiyun1963@163.com.
6
China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China. liubaiyun1963@163.com.
7
Beijing Key Laboratory of Central Nervous System Injury, Beijing, 100050, China. liubaiyun1963@163.com.

Abstract

Tanycytic ependymoma is a rare subtybe of ependymoma with a predilection for the spinal cord and intracranial tanycytic ependymoma is thus extremely rare. Most studies on intracranial tanycytic ependymomas included only one or two cases. Here we report nine patients with pathologically confirmed intracranial tanycytic ependymomas. The clinical characteristics, including radiological and histological examination, operative records, and prognoses were reviewed. The case series included six male and three female patients with an average age of 19.3 years. Tumors were located in the lateral ventricle (3/9), the fourth ventricle (2/9), and the supratentorial extraventricle (4/9). Gross total resection (GTR) of the tumor was achieves in seven cases, and subtotal resection (STR) was achieved in the other two cases. One patient died 21 months after discharge. The left eight patients showed improved symptoms after surgery, and no tumor recurrence was found in these cases during the follow-up. It seems that intracranial tanycytic ependymoma has the best long-term prognosis compared to the other two subtypes of ependymoma. According to our experience, we recommend surgery including GTR and STR followed by radiotherapy for patients with intracranial tanycytic ependymomas.

KEYWORDS:

Clinical features; Intracranial; Prognosis; Surgical outcomes; Tanycytic ependymoma

PMID:
28653235
DOI:
10.1007/s11060-017-2531-8
[Indexed for MEDLINE]

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