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Curr Allergy Asthma Rep. 2017 Aug;17(8):54. doi: 10.1007/s11882-017-0721-2.

Eosinophilic Esophagitis in Children.

Author information

1
The Children's Hospital of Philadelphia, Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.
2
The Children's Hospital of Philadelphia, Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA. spergel@email.chop.edu.
3
The Children's Hospital of Philadelphia, Division of Allergy and Immunology, Buerger Center for Advanced Pediatric Care, Sixth Floor, 3500 Civic Center Boulevard, Philadelphia, PA, 19104, USA. spergel@email.chop.edu.

Abstract

PURPOSE OF REVIEW:

EoE is a significant cause of gastrointestinal morbidity affecting 1:2000. Patients with EoE typically have multiple atopic comorbidities, and additionally, many patients with EoE can be controlled well with elimination diets. The purpose of this review is to summarize the care of pediatric eosinophilic esophagitis patients.

RECENT FINDINGS:

EoE represents a distinct clinical syndrome which is characterized by esophageal dysfunction and eosinophil-predominant inflammation of the esophageal mucosa. Patients with EoE can present with varying symptoms depending on their age; in this review, we review the presenting features of eosinophilic esophagitis in children as well as a diagnostic algorithm for EoE. The mucosal inflammation in EoE is driven by exposure to food antigens in many patients with EoE. Therefore, for the majority of patients, the mainstays of treatment remain food elimination diets or swallowed steroids. This review summarizes the diagnostic approach to eosinophilic esophagitis (EoE) in pediatric patients, focusing on the importance of accurate diagnosis and selection of appropriate therapy.

KEYWORDS:

Eosinophilic esophagitis (EoE); Food allergy; Non-IgE mediated food allergy; Pediatric allergy

PMID:
28653125
DOI:
10.1007/s11882-017-0721-2
[Indexed for MEDLINE]

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