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World J Gastroenterol. 2017 Jun 14;23(22):4132-4134. doi: 10.3748/wjg.v23.i22.4132.

Is tremor related to celiac disease?

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Lucia Ameghino, Malco Damian Rossi, Daniel Cerquetti, Marcelo Merello, Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research, Buenos Aires C1428AQK, Argentina.


Neurological features in celiac disease (CD) are not rare (5%-36%), but tremor is scarcely described. Subjects with CD and healthy controls completed an online survey using WHIGET tremor rating scale. One thousand five hundred and twelve subjects completed the survey, finally 674 CD patients and 290 healthy subjects were included. A higher prevalence of tremor in CD patients was observed in comparison to controls (28% vs 14%, P < 0.001). Frequency of family history of tremor in CD patients with and without tremor was 25% and 20% (P = 0.2), while in the control group it was 41% and 10% (P < 0.001). Controls with tremor showed a higher frequency of family history of tremor when compared to CD patients with tremor (41.5% vs 24.6%, P = 0.03). The results suggested that tremor in CD might be more frequent and possibly related to the disease itself and not due to associated essential tremor.


Celiac disease; Gluten; Gluten-free diet; Movement disorders; Tremor

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