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J Biol Chem. 2017 Aug 25;292(34):13925-13933. doi: 10.1074/jbc.R116.774745. Epub 2017 Jun 26.

Current prospects of type II interferon γ signaling and autoimmunity.

Author information

1
From the Women's Malignancy Branch, Translational Genomics Section, Center for Cancer, NCI, National Institutes of Health, Bethesda, Maryland 20892 and.
2
the Cancer and Inflammation Program, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702-1201 Younghow@nih.gov.
3
the Cancer and Inflammation Program, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702-1201 valencij@mail.nih.gov.

Abstract

Interferon γ (IFNγ) is a pleiotropic protein secreted by immune cells. IFNγ signals through the IFNγ receptor, a protein complex that mediates downstream signaling events. Studies into IFNγ signaling have provided insight into the general concepts of receptor signaling, receptor internalization, regulation of distinct signaling pathways, and transcriptional regulation. Although IFNγ is the central mediator of the adaptive immune response to pathogens, it has been shown to be involved in several non-infectious physiological processes. This review will provide an introduction into IFNγ signaling biology and the functional roles of IFNγ in the autoimmune response.

KEYWORDS:

autoimmune disease; autoimmunity; interferon; signal transducers and activators of transcription 1 (STAT1); signaling

PMID:
28652404
PMCID:
PMC5572907
DOI:
10.1074/jbc.R116.774745
[Indexed for MEDLINE]
Free PMC Article

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