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Inhal Toxicol. 2017 Mar;29(4):179-185. doi: 10.1080/08958378.2017.1336187. Epub 2017 Jun 27.

Cosmetic talc as a risk factor for pleural mesothelioma: a weight of evidence evaluation of the epidemiology.

Author information

1
a Cardno ChemRisk , Brooklyn , NY , USA.
2
b Cardno ChemRisk , Pittsburgh , PA , USA.
3
c University of Pittsburgh Center for Occupational Biostatistics & Epidemiology , Pittsburgh , PA USA.

Abstract

OBJECTIVE:

Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of individuals exposed to cosmetic talc.

MATERIALS AND METHODS:

We conducted a systematic review of the epidemiological literature for cosmetic talc miners and millers and found three occupational cohort studies that evaluated pleural mesothelioma incidence in workers in Italy, Norway, France, and Austria. We conducted a second literature review to evaluate the incidence and mortality of pleural mesothelioma among patients who received talc pleurodesis treatments before 1965 and found retrospective clinical studies including over 300 patients with follow-up ranging from 14 to 40 years.

RESULTS:

There were no mesotheliomas reported in any of the cosmetic talc miner and miller cohorts. A pooled analysis of data from the cohort mortality studies indicated that four mesothelioma deaths would have been expected from the 90,022 person-years of observation, and this was associated with 84% and 67% statistical power to observe a 3-fold or 2.5-fold increase in pleural mesothelioma mortality, respectively. None of the patients who received talc pleurodesis treatments developed mesothelioma.

CONCLUSION:

We conclude that there is no epidemiological evidence to support the hypothesis that exposure to cosmetic talc is associated with the development of pleural mesothelioma.

KEYWORDS:

Mesothelioma; cosmetic talc; millers; miners; pleurodesis; statistical power calculation

PMID:
28651470
DOI:
10.1080/08958378.2017.1336187
[Indexed for MEDLINE]

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