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Eur J Cancer. 2017 Sep;82:16-24. doi: 10.1016/j.ejca.2017.04.025. Epub 2017 Jun 23.

Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.

Collaborators (325)

Thaler J16, Greil R17, Gaenzer J18, Eisterer W19, Tschmelitsch J20, Keil F21, Samonigg H22, Zabernigg A23, Schmid F24, Steger G25, Steinacher R26, Andel J27, Jagdt B28, Lang A29, Fridrik M30, Függer R31, Hofbauer F32, Woell E33, Geissler D34, Lenauer A35, Prager M36, D'Haens G37, Demolin G38, Kerger J39, Deboever G40, Ghillebert G41, Polus M42, Van Cutsem E43, Kalantari HR44, Delaunoit T45, Goeminne JC46, Peeters M47, Vergauwe P48, Houbiers G49, Humblet Y50, Janssens J51, Schrijvers D52, Vanderstraeten E53, Van Laethem JL54, Vermorken J55, Van Daele D56, Ferrante M57, Forget F58, Hendlisz A59, Yilmaz M60, Nielsen SE61, Vestermark L62, Larsen J63, Zawadi MA64, Bouche O65, Mineur L66, Bennouna-Louridi J67, Dourthe LM68, Ychou M69, Boucher E70, Taieb J71, Pezet D72, Desseigne F73, Ducreux M74, Texereau P75, Miglianico L76, Rougier P71, Fratte S77, Levache CB78, Merrouche Y79, Ellis S80, Locher C81, Ramee JF82, Garnier C83, Viret F84, Chauffert B85, Cojean-Zelek I86, Michel P87, Lecaille C88, Borel C89, Seitz JF90, Smith D91, Lombard-Bohas C92, Andre T93, Gornet JM94, Fein F95, Coulon-Sfairi MA96, Kaminsky MC97, Lagasse JP98, Luet D99, Etienne PL100, Gasmi M101, Vanoli A102, Nguyen S103, Aparicio T104, Perrier H105, Stremsdoerfer N106, Laplaige P107, Arsene D108, Auby D109, Bedenne L110, Coriat R111, Denis B112, Geoffroy P113, Piot G114, Becouarn Y115, Bordes G116, Deplanque G117, Dupuis O118, Fruge F119, Guimbaud R120, Lecomte T121, Lledo G122, Sobhani I123, Asnacios A124, Azzedine A125, Desauw C126, Galais MP127, Gargot D128, Lam YH129, Abakar-Mahamat A130, Berdah JF131, Catteau S132, Clavero-Fabri MC133, Codoul JF134, Legoux JL135, Goldfain D136, Guichard P137, Verge DP138, Provencal J139, Vedrenne B140, Brezault-Bonnet C141, Cleau D142, Desir JP143, Fallik D144, Garcia B145, Gaspard MH146, Genet D147, Hartwig J148, Krummel Y149, Budnik TM150, Palascak-Juif V151, Randrianarivelo H152, Rinaldi Y153, Aleba A154, Darut-Jouve A155, de Gramont A156, Hamon H157, Wendehenne F158, Matzdorff A159, Stahl MK160, Schepp W161, Burk M162, Mueller L163, Folprecht G164, Geissler M165, Mantovani-Loeffler L166, Hoehler T167, Asperger W168, Kroening H169, von Weikersthal LF170, Fuxius S171, Groschek M172, Meiler J173, Trarbach T173, Rauh J174, Ziegenhagen N175, Kretzschmar A175, Graeven U176, Nusch A177, von Wichert G178, Hofheinz RD179, Kleber G180, Schmidt KH181, Vehling-Kaiser U182, Baum C183, Schuette J183, Haag GM184, Holtkamp W185, Potenberg J186, Reiber T187, Schliesser G188, Schmoll HJ189, Schneider-Kappus W190, Abenhardt W191, Denzlinger C192, Henning J193, Marxsen B193, Derigs HG194, Lambertz H195, Becker-Boost I196, Caca K197, Constantin C198, Decker T199, Eschenburg H200, Gabius S201, Hebart H202, Hoffmeister A203, Horst HA204, Kremers S205, Leithaeuser M206, Mueller S207, Wagner S208, Daum S209, Schlegel F210, Stauch M211, Heinemann V212, Maiello E213, Latini L214, Zaniboni A215, Amadori D216, Aprile G217, Barni S218, Mattioli R219, Martoni A220, Passalacqua R221, Nicolini M222, Pasquini E222, Rabbi C223, Aitini E223, Ravaioli A224, Barone C225, Biasco G226, Tamberi S227, Gambi A227, Verusio C228, Marzola M229, Lelli G229, Boni C230, Cascinu S231, Bidoli P232, Vaghi M232, Cruciani G233, Di Costanzo F234, Sobrero A235, Mini E236, Petrioli R237, Aglietta M238, Alabiso O239, Capuzzo F240, Falcone A240, Corsi DC241, Labianca R242, Salvagni S243, Chiara S244, Ciuffreda L245, Ferraù F246, Giuliani F247, Lonardi S248, Gebbia N249, Mantovani G250, Sanches E251, Mellidez JC252, Santos P253, Freire J254, Sarmento C255, Costa L256, Pinto AM257, Barroso S258, Santo JE259, Guedes F260, Monteiro A261, Sa A262, Furtado I263, Salazar R264, Aguilar EA265, Herrero FR266, Tabernero J267, Valera JS268, Ayerbes MV269, Batlle JF270, Gil S271, Esteve AA272, Garcia-Giron C273, Vivanco GL274, Salvia AS275, Orduña VA276, Garcia RV277, Gallego J278, Sureda BM279, Remon J280, Safont Aguilera MJ281, Nogueras LC282, Merino BQ283, Castro CG284, de Prado PM285, Pericay CP286, Figueiras MC287, Jordan IG288, Gome Reina MJ289, Garcia AL290, Garcia-Ramos AA291, Cervantes A292, Martos CF293, Gaspar EM294, Montero IC295, Emperador PE296, Carbonero AL297, Castillo MG298, Garcia TG299, Lopez JG300, Flores EG301, Morales MG302, Muñoz ML303, Martín AL304, Maurel J305, Camara JC306, Garcia RD307, Salgado M308, Busquier IH309, Ruiz TC310, Muñoa AL311, Aliguer MN312, de Taranco AVO313, Ureña MM314, Gaspa FL315, Ponce JJ316, Roig CB317, Jimenez PV318, Brotons AG319, Rodriguez SA320, Martinez JA321, Ruiz LC322, Ruiz MC323, Bridgewater J324, Glynne-Jones R325, Tahir S326, Hickish T327, Cassidy J328, Samuel L329.

Author information

1
EA4340, Versailles University, Paris-Saclay University, Boulogne, France; Assistance Publique Hôpitaux de Paris, Hopital Ambroise Paré, Boulogne, France. Electronic address: jean-francois.emile@uvsq.fr.
2
EA4340, Versailles University, Paris-Saclay University, Boulogne, France; Assistance Publique Hôpitaux de Paris, Hopital Ambroise Paré, Boulogne, France.
3
Fédération Francophone de Cancérologie Digestive (FFCD), Dijon, France.
4
Fédération Francophone de Cancérologie Digestive (FFCD), Dijon, France; Department of Hepato-Gastroenterology, Dijon University Hospital, Dijon, France; UMR 866, INSERM, Dijon, France.
5
Vall D'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.
6
Section of Internal Medicine, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
7
Medical Department I, University Hospital Carl Gustav Carus, Dresden, Germany.
8
Department of Gastroenterology, Erasme Hospital University, Brussels, Belgium.
9
Department of Pathology, Hospital of La Roche sur Yon, La Roche sur Yon, France.
10
Department of Pathology, University Hospital of Reims, Reims, France.
11
EA4340, Versailles University, Paris-Saclay University, Boulogne, France.
12
Department of Pathology, Centre Jean Perrin, Clermont-Ferrand, France.
13
Department of Gastroenterology, Centre Rene Gauducheau, Saint-Herblain, France.
14
Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Assistance Publique Hôpitaux de Paris, Department of Biology, Hôpital Européen Georges Pompidou, Paris, France; INSERM UMR-S1147 Centre Universitaire des Saints Pères, Paris, France.
15
Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Paris Descartes University, Paris Sorbonne cité, Department of Digestive Oncology, HEGP, Paris, France.
16
Klinikum Kreuzschwestern Wels, Wels, Austria.
17
LKH Salzburg, Austria.
18
BKH Hall in Tirol, Hall in Tirol, Austria.
19
University Klinik Innsbruck, Innsbruck, Austria.
20
KH Barmherzigen Brüder St. Veit/Glan, Austria.
21
LKH Leoben, Leoben, Austria.
22
Landeskrankenhaus Graz Medizinische Universitätsklinik, Graz, Austria.
23
BKH Kufstein, Kuftstein, Austria.
24
LKH Bregenz, Bregenz, Austria.
25
Universitätsklinik für Innere Medizin I, Wein, Austria.
26
LKH Wolfsberg, LKH, Austria.
27
LKH Steyr, Steyr, Austria.
28
A.ö.Krankenhaus D. Barmherz. Schwest. Ried, Ried, Austria.
29
LKH Rankweil, Rankweil, Austria.
30
AKH Linz, Linz, Austria.
31
A.ö. Krankenhaus D. Elisabethinen Linz, Austria.
32
LKH Oberpullendorf, Oberpullendorf, Austria.
33
KH St. Vinzenz Zams, Zams, Austria.
34
LKH Klagenfurt, Klagenfurt, Austria.
35
KH Wiener Neustadt, Wiener Neustadt, Austria.
36
A.ö. KH Oberwart, Oberwart, Austria.
37
Imelda Ziekenhuis, Bonheiden, Belgium.
38
Clinique St-Jospeh, Liège, Belgium.
39
Cliniques Universitaires de Mont-Godinne U.C.L., Yvoir, Belgium.
40
A.Z. St-Jozef, Oostende, Belgium.
41
Heilig Hart Ziekenhuis, Roeselare, Belgium.
42
C.H.U. Sart-Tilman, Liège, Belgium.
43
University Hospitals, Leuven, Belgium.
44
C.H. Peltzer-La Tourelle, Verviers, Belgium.
45
Centre Hospitalier de Jolimont-Lobbes, La Louvière, Belgium.
46
Clinique et Maternité Sainte-Elisabeth, Namur, Belgium.
47
Universitair Ziekenhuis Gent, Gent, Belgium.
48
AZ Groeninge-Campus Kennedylaan, Kortrijk, Belgium.
49
Centre Médical de L'Avenue, Liege, Belgium.
50
Cliniques Universitaires Saint-Luc, Brussels, Belgium.
51
St-Elisabeth Ziekenhuis, Turnhout, Belgium.
52
ZNA Middelheim, Antwerpen, Belgium.
53
AZ Maria Middelares, Gent, Belgium.
54
ULB Hôpital Erasme, Brussels, Belgium.
55
UZ Antwerpen, Edegem, Belgium.
56
Clinique Nôtre-Dame de Grâce, Gosselies, Belgium.
57
AZ Sint-Maarten, Mechelen, Belgium.
58
Centre Hospitalier de L'Ardenne, Libramont, Belgium.
59
Jules Bordetinstituut, Brussels, Belgium.
60
Aalborg Sygehus-Afsnit Syd, Aalborg, Denmark.
61
Hillerød Hospital, Hillerød, Denmark.
62
Odense Universitets Hospital, Odense, Denmark.
63
Roskilde Amtssygehus, Roskilde, France.
64
Centre Hospitalier Les Oudairies, La Roche sur Yon, France.
65
CHU de Reims, Hopital Robert Debre, Reims, France.
66
Institut Sainte Catherine, Avignon, France.
67
CRLCC René Gauducheau, St Herblain, France.
68
Clinique Sainte Anne, Strasbourg, France.
69
Centre Regional Val D'Aurelle Paul Lamarque, Montpellier, France.
70
CRLC Eugène Marquis, Rennes, France.
71
Hôpital Européen Georges Pompidou, Paris, France.
72
CHU Estaing, Clermond Ferrand, France.
73
Centre Leon Berard, Lyon, France.
74
Institut Gustave Roussy Villejuif, France.
75
Hopital Layne, Mont-de-Marsan, France.
76
Centre Hospitalier Privé Saint- Grégoire (Rennes), Saint-Grégoire, France.
77
Centre Hospitalier de Belfort-Montbeliard, Belfort, France.
78
Polyclinique Francheville, Perigueux, France.
79
Institut de Cancerologie de La Loire, Saint-Priest-En-Jarez, France.
80
Clinique Saint Pierre, Perpignan, France.
81
CH Meaux, Meaux, France.
82
Centre Catherine de Sienne, Nantes, France.
83
UMGEC-Institut Daniel Hollard, Grenoble, France.
84
Institut Paoli Calmettes, Marseille, France.
85
Centre Georges François Leclerc, Dijon, France.
86
Hopital Croix Saint Simon, Paris, France.
87
Hopital Charles Nicolle, Rouen, France.
88
Polyclinique Bordeaux Nord Aquitaine, Bordeaux, France.
89
CLCC Paul Strauss, Strasbourg, France.
90
CHU de La Timone, Marseille, France.
91
Groupe Hospitalier Saint-Andre, Bordeaux, France.
92
Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.
93
Groupe Hospitalier Pitie-Salpetriere, Paris, France.
94
Hopital Saint Louis, Paris, France.
95
CHU de Besancon, Hopital Jean Minjoz, Besançon, France.
96
Centre Hospitalier Du Mans, Le Mans, France.
97
Centre Alexis Vautrin Brabois, Vandoeuvre les Nancy, France.
98
CHR D' Orléans La Source, Orléans, France.
99
CRLCC Paul Papin, Angiers, France.
100
Clinique Armoricaine de Radiologie, Saint-Brieux, France.
101
Hopital Nord de Marseille, Marseille, France.
102
Clinique Ste-Marie, Chalon Sur Saone, France.
103
Centre Hospitalier de Beauvais, Beauvais, France.
104
Hôpital Bichat, Paris, France.
105
Hopital Saint Joseph, Marseille, France.
106
Hopital Pierre Oudot, Bourgoin-Jallieux, France.
107
Clinique Saint Côme, La Chaussée St Victor, France.
108
CHU de Caen, Caen, France.
109
Hôpital Robert Boulin, Libourne, France.
110
Hopital Du Bocage, Dijon, France.
111
Hopital Cochin, Paris, France.
112
Hopital Pasteur, Colmar, France.
113
Clinique Saint-Vincent, Epernay, France.
114
Clinique des Ormeaux, Le Havre, France.
115
CHU de Bordeaux, Bordeaux, France.
116
Centre Hospitalier de Digne Les Bains, Digne Les Bains, France.
117
Hopital Saint Joseph, Paris, France.
118
Clinique Victor Hugo, Le Mans, France.
119
CHU Poitiers-Hôpital La Milétrie, Poitiers, France.
120
Hopital Purpan, Toulouse, France.
121
Hopital Trousseau - CHU de Tours, Tours, France.
122
Hopital Prive Jean Mermoz, Lyon, France.
123
Hôpital Henri Mondor (Gastro-Entérologie), Créteil, France.
124
Hopital Antoine Beclere, Clamart, France.
125
Boulat, Michel, Avignon, France.
126
Hopital Saint Vincent de Paul-GHICL Lille, Lille, France.
127
Centre François Baclesse, Caen, France.
128
Centre Hospitalier de Blois, Blois, France.
129
Hopital de Cholet, Cholet, France.
130
Hopital L'Archet II, Nice, France.
131
Clinique Sainte Marguerite, Hyères, France.
132
Hopital Duchenne, Boulogne sur Mer, France.
133
Clinique Hartman, Levallois Perret, France.
134
Hopital de Draguignan, Draguignan, France.
135
Hôpital Haut Levêque, Pessac, France.
136
Centre Hospitalier General de Dreux, Dreux, France.
137
Clinique des Quatre Pavillons, Lormont, France.
138
Hôpital de La Croix Rousse (Gastroentérologie), Lyon, France.
139
Centre Hospitalier D'Annecy, Pringy, France.
140
Hopital E. Muller, Mulhouse, France.
141
Hopital de Rambouillet, Rambouillet, France.
142
Centre Hospitalier Intercommunal de Vesoul, Vesoul, France.
143
Clinique Pole Sante Republique, Clermont-Ferrand, France.
144
Polyclinic Jeanne D'Arc Gien, France.
145
Clinique de Courlancy, Reims, France.
146
Clinique Claude Bernard, Albi, France.
147
Centre de Cancerologie Chenieux, Limoges, France.
148
Infirmerie Protestante de Lyon, Caluire et Cuire, France.
149
Centre Hospitalier Selestat, Selestat, France.
150
CH de Nantes Hotel Dieu, Nantes, France.
151
Hopital de Hautepierre, Strasbourg, France.
152
Centre Frederic Joliot, Rouen, France.
153
Clinique Clairval, Marseille, France.
154
Centre Hospitalier de Niort, Hopital Georges Renon, Niort, France.
155
Centre D'oncologie et Radiotherapie, Dijon, France.
156
Hopital Saint Antoine, Paris, France.
157
Centre Hospitalier de Valence, Valence, France.
158
Clinique Charcot, Sainte-Foy-les-Lyon, France.
159
Caritasklinik St. Theresia, Saarbruecken, Germany.
160
Kliniken Essen-Mitte-PS, Essen, Germany.
161
KKH Muenchen Bogenhausen, Muenchen, Germany.
162
Klinikum der Stadt Hanau, Hanau, Germany.
163
Onkologische Schwerpunktpraxis, Leer, Germany.
164
Universitaetsklinikum Carl Gustav Carus, Dresden, Germany.
165
Staedtische Kliniken Esslingen, Esslingen, Germany.
166
Staedtisches Klinikum St. Georg Leipzig, Leipzig, Germany.
167
Prosper-Hospital, Recklinghausen, Germany.
168
Krankenhaus St. Elisabeth und St. Barbara, Halle, Germany.
169
Gemeinschaftspraxis, Magdeburg, Germany.
170
MVZ Gesundheitszentrum St. Marien GmbH, Amberg, Germany.
171
Onkologische Praxis, Heidelberg, Germany.
172
Haematologisch-Onkologische Praxis Wuerselen, Wuelselen, Germany.
173
Universitaetsklinikum Essen, Essen, Germany.
174
Gemeinschaftspraxis Ardeystrasse, Witten, Germany.
175
Helios-Kliniken Berlin, Berlin, Germany.
176
Kliniken Maria Hilf GmbH, Moenchengladbach, Germany.
177
Onkologische Praxis, Velbert, Germany.
178
Universitaetsklinikum, Ulm, Germany.
179
Klinikum der Stadt Mannheim, Mannheim, Germany.
180
Ostalb-Klinikum Aalen, Aalen, Germany.
181
Johanniter-Krankenhaus Rheinhausen, Duisberg, Germany.
182
Gemeinschaftspraxis, Landshut, Germany.
183
Marien Hospital Duesseldorf GmbH, Duesseldorf, Germany.
184
Universitaetsklinikum Heidelberg, Heidelberg, Germany.
185
Ammerland-Klinik GmbH, Westerstede, Germany.
186
Evangelisches Waldkrankenhaus, Berlin, Germany.
187
Praxis Fuer Haematologie/Onkologie, Freiberg, Germany.
188
Praxis Fuer Haematologie und Onkologie, Giessen, Germany.
189
Martin-Luther-Universitaet Halle-Wittenberg, Halle, Germany.
190
Arztpraxis, Ulm, Germany.
191
Onkologie Praxis Im Elisenhof, Muenchen, Germany.
192
Marienhospital Stuttgart, Stuggart, Germany.
193
Universitaetsklinikum Schleswig-Holstein, Luebeck, Germany.
194
Staedtische Kliniken Frankfurt-Hoechst, Frankfurt, Germany.
195
Klinikum Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany.
196
MVZ Duisburg Sued GmbH, Duisburg, Germany.
197
Klinikum Ludwigsburg, Ludwigsburg, Germany.
198
Kliniken Lippe-Lemgo GmbH, Lemgo, Germany.
199
Gemeinschaftspraxis, Ravensburg, Germany.
200
Internistische Gemeinschaftspraxis, Guestrow, Germany.
201
Gemeinschaftspraxis, Rosenheim, Germany.
202
Klinikum Schwaebisch Gmuend-Stauferklinik, Mutlangen, Germany.
203
Universitaetsklinikum Leipzig, Leipzig, Germany.
204
Universitaetsklinikum Schleswig-Holstein-Campus Kiel, Kiel, Germany.
205
Caritas-Krankenhaus, Lebach, Germany.
206
Universitaetsmedizin Rostock, Rostock, Germany.
207
Ambulantes Onkologie Zentrum, Ansbach, Germany.
208
Klinikum Deggendorf, Deggendorf, Germany.
209
Charité Universitaetsmedizin Berlin-Campus Charité Mitte, Berlin, Germany.
210
St. Antonius-Hospital, Eschweiler, Germany.
211
Onkologische Schwerpunktpraxis, Kronach, Germany.
212
Klinikum der Ludwig-Maximilians-Universitaet, Muenchen, Germany.
213
IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy.
214
Ospedale di Macerata, Macerata, Italy.
215
Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
216
Istituto Scientifico Romagnolo per Lo Studio e La Cura Dei Tumori, Meldola, Italy.
217
Az. Policlinico Universitario di Udine, Udine, Italy.
218
Azienda Ospedaliera Treviglio-Caravaggio, Treviglio, Italy.
219
Ospedale Santa Croce ASUR 3, Fano, Italy.
220
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Ma, Bologna, Italy.
221
Azienda Ospedaliera Istituti Ospitalieri di Cremona, Cremona, Italy.
222
Ospedale Cervesi, Cattolica, Italy.
223
Azienda Ospedaliera Carlo Poma, Mantova, Italy.
224
Ospedale Degli Infermi, Rimini, Italy.
225
Policlinico Universitario Agostino Gemelli, Roma, Italy.
226
Ospedale Marcello Malpighi Policlinico Sant'Orsola, Bologna, Italy.
227
Ospedale Degli Infermi, Faenza, Italy.
228
Ospedale di Saronno, Saronno, Italy.
229
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna, Cona, Ferrara, Italy.
230
A.O. Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
231
Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy.
232
Azienda Ospedaliera San Gerardo, Monza, Italy.
233
Ospedale Umberto I, Luggo, Italy.
234
Azienda Ospedaliera Universitaria Careggi, Firenze, Italy.
235
Azienda Ospedaliera San Martino, Genoa, Italy.
236
A.O. Universitaria Careggi, Firenze, Italy.
237
A.O.U. Senese Policlinico Santa Maria Alle Scotte, Siena, Italy.
238
Istituto per La Ricerca e La Cura Del Cancro, Candiolo, Italy.
239
Ospedale Maggiore Della Carità, Novara, Italy.
240
Presidio Ospedaliero di Livorno, Livorno, Italy.
241
Ospedale "S. Giov. Calibita" Fatebenefratelli, Roma, Italy.
242
Ospedali Riuniti di Bergamo, Bergamo, Italy.
243
Azienda Ospedaliera di Parma, Parma, Italy.
244
Istituto Nazionale per La Ricerca Sul Cancro, Genova, Italy.
245
A.O. San Giovanni Battista, Torino, Italy.
246
Azienda Ospedaliera San Vincenzo, Taormina, Italy.
247
Istituto Oncologico Giovanni Paolo II IRCCS, Bari, Italy.
248
IOV-Istituto Oncologico Veneto IRCCS, Padova, Italy.
249
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone, Palermo, Italy.
250
Università di Cagliari-Presidio Policlinico Monserrato, Monserrato, Italy.
251
Instituto Português de Oncologia Do Porto Francisco Gentil, Porto, Portugal.
252
Hospital Distrital de Aveiro, Aveiro, Portugal.
253
Hospital São Sebastião, EPE, Santa Maria da Feira, Portugal.
254
Instituto Portugues de Oncologia, Lison, Portugal.
255
Hospital de Sao Joao, Porto, Portugal.
256
Hospital de Santa Maria, Lisbon, Portugal.
257
Hospital Geral de Santo Antonio, Porto, Portugal.
258
Hospital Distrital de Beja, Beja, Portugal.
259
Hospital Do Barreiro, Barreiro, Portugal.
260
Hospital Distrital Figueira da Foz, EPE, Figueira da Foz, Portugal.
261
Hospital São Teotónio, EPE, Viseu, Portugal.
262
Hospitais da Universidade de Coimbra, Coimbra, Portugal.
263
Hospital Distrital de Faro, Faro, Portugal.
264
ICO L'Hospitalet Hospital Duran I Reynals, Barcelona, Spain.
265
Hospital Reina Sofia, Cordoba, Spain.
266
Hospital Universitario Marques de Valdecilla, Santander, Spain.
267
Hospital. Vall D'Hebron, Barcelona, Spain.
268
Hospital Clinico San Carlos, Madrid, Spain.
269
Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.
270
Hospital Universitario La Paz, Madrid, Spain.
271
Hospital Carlos Haya, Malaga, Spain.
272
ICO Badalona-Hospital Germans Trias I Pujol, Barcelona, Spain.
273
Hospital Universitario de Burgos, Burgos, Spain.
274
Hospital de Cruces, Vizcaya, Spain.
275
Hospital Universitario de Lleida Arnau de Vilanova, Lleida, Spain.
276
Hospital Miguel Servet, Zaragoza, Spain.
277
Complejo Hospitalario de Navarra, Pamplona, Spain.
278
HGU de Elche, Elche-Alicante, Spain.
279
Hospital General Universitario de Alicante, Alicante, Spain.
280
Hospital de Mataro, Barcelona, Spain.
281
Hospital General Universitario de Valencia, Valencia, Spain.
282
Hospital Mutua de Terrassa, Barcelona, Spain.
283
Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain.
284
Hospital 12 de Octubre, Madrid, Spain.
285
Hospital de Basurto, Bilbao, Spain.
286
Consorci Hospitalari Parc Tauli, Barcelona, Spain.
287
Hospital Provincial de Pontevedra, Pontevedra, Spain.
288
Hospital Sant Joan de Deu de Manresa, Manresa, Spain.
289
Hospital Del Mar, Cadiz, Spain.
290
Hospital El Tomillar-Ntra Sra de Valme, Sevilla, Spain.
291
Fundacion Hospital Son Llatzer, Palma Mallorca, Spain.
292
Hospital Clinico Universitario de Valencia, Valencia, Spain.
293
Instituto Valenciano de Oncologia, Valencia, Spain.
294
Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
295
Hospital Universitario Sant Joan de Reus, Tarragona, Spain.
296
Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain.
297
Fundacion Jimenez Diaz, Madrid, Spain.
298
Hospital Del Mar, Barcelona, Spain.
299
Hospital Morales Meseguer, Murcia, Spain.
300
Hospital Universitario Ramón y Cajal, Madrid, Spain.
301
Hospital Virgen de las Nieves Ruiz de Alda, Granada, Spain.
302
Hospital Son Espases, Palma de Mallorca, Spain.
303
Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
304
Hospital Severo Ochoa, Spain.
305
Hospital Clinic I Provincial, Barcelona, Spain.
306
Fundacion Hospital Alcorcon, Madrid, Spain.
307
Hospital Ciudad de Jaen, Jaen, Spain.
308
Complejo Hospitalario Ourense, Ourense, Spain.
309
Hospital Provincial Castellon, Castellon, Spain.
310
Instituto de Oncologia Corachan, Barcelona, Spain.
311
Hospital. de Donostia, San Sebastian, Spain.
312
Hospital General de Vic, Vic, Spain.
313
Hospital Universitario de La Princesa, Madrid, Spain.
314
Hospital General de Mostoles, Mostoles, Spain.
315
Consorci Sanitari Creu Roja, Barcelona, Spain.
316
Hospital Virgen de Los Lirios, Alicante, Spain.
317
Hospital Universitario. Dr. Peset, Valencia, Spain.
318
Clínica Infanta Luisa, Sevilla, Spain.
319
Hospital Sagunto, Sagunto, Spain.
320
Hospital Espiritu Santo, Barcelona, Spain.
321
Hospital Ruber Internacional de Madrid, Madrid, Spain.
322
Hospital Torrecardenas, Almeria, Spain.
323
Hospital Sagrat Cor, Barcelona, Spain.
324
North Middlesex University Hospital NHS Trust, London, United Kingdom.
325
Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, London, United Kingdom.
326
Broomfield Hospital, Chelmsford, United Kingdom.
327
Poole Hospital NHS Trust, Poole and Bournemouth Hospital, Bournemouth, United Kingdom.
328
Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
329
Aberdeen Royal Infirmary, Aberdeen, United Kingdom.

Abstract

BACKGROUND:

The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use.

PATIENTS AND METHODS:

According to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study. Primary objective was to compare percentage of patients alive and without recurrence at 2 years in patients with high versus low LI (#NCT02364024). Associations of LI with patient recurrence and survival were analysed, and multivariable models were adjusted for treatment and relevant factors. Automated testing of LI was performed on virtual slides without access to clinical data.

RESULTS:

Among the 1220 CC patients enrolled, LI was high, low and not evaluable in 241 (19.8%), 790 (64.8%) and 189 (15.5%), respectively. Primary objective was met with a 2-year recurrence rate of 14.4% versus 21.1% in patients with high and low LI, respectively (p = 0.02). Patients with high LI also had better disease free survival (DFS) and overall survival (OS). Tumour stage, grade, RAS status and BRAF status were with LI the only prognostic markers in multivariable analysis for OS. Subgroup analyses revealed that high LI had better DFS and OS in mismatch repair (MMR) proficient patients, and in patients without RAS mutation, but not in MMR deficient and RAS mutated patients.

CONCLUSION:

Although this is the first validation with high level of evidence (IIB) of the prognostic value of a LI test in colon cancers, it still needs to be confirmed in independent series of colon cancer patients.

KEYWORDS:

Biomarker; Colorectal carcinoma; Immune response; Prospective cohort study

PMID:
28651158
DOI:
10.1016/j.ejca.2017.04.025
[Indexed for MEDLINE]

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