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Adv Mater. 2017 Aug;29(32). doi: 10.1002/adma.201606471. Epub 2017 Jun 26.

Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion.

Author information

1
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, CA, 90095, USA.
2
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 621 Charles Young Drive, CA, 90095, USA.
3
Department of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, 200 UCLA Medical Plaza, 90095, USA.

Abstract

With the number of deaths due to stroke decreasing, more individuals are forced to live with crippling disability resulting from the stroke. To date, no therapeutics exist after the first 4.5 h after the stroke onset, aside from rest and physical therapy. Following stroke, a large influx of astrocytes and microglia releasing proinflammatory cytokines leads to dramatic inflammation and glial scar formation, affecting brain tissue's ability to repair itself. Pathological conditions, such as a stroke, trigger neural progenitor cells (NPCs) proliferation and migration toward the damaged site. However, these progenitors are often found far from the cavity or the peri-infarct tissue. Poststroke tissue remodeling results in a compartmentalized cavity that can directly accept a therapeutic material injection. Here, this paper shows that the injection of a porous hyaluronic acid hydrogel into the stroke cavity significantly reduces the inflammatory response following stroke while increasing peri-infarct vascularization compared to nonporous hydrogel controls and stroke only controls. In addition, it is shown that the injection of this material impacts NPCs proliferation and migration at the subventricular zone niche and results, for the first time, in NPC migration into the stroke site.

KEYWORDS:

inflammation; neural progenitor cells; particle hydrogels; porous hydrogels; stroke

PMID:
28650574
PMCID:
PMC5595584
DOI:
10.1002/adma.201606471
[Indexed for MEDLINE]
Free PMC Article

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