Format

Send to

Choose Destination
J Oral Pathol Med. 2017 Nov;46(10):998-1003. doi: 10.1111/jop.12609. Epub 2017 Jul 24.

Circulating high mobility group AT-hook 2 and pleomorphic adenoma gene 1 in blood of patients with oral squamous cell carcinoma.

Ren W1,2, Gao L1,2,3, Li F3, Qiang C2, Li S1, Zheng J2,4, Kong X5, Deng J4, Cai G2, Zhang H2, Zhou M1,3, Zhi K1,2,3.

Author information

1
Department of Oral Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
2
Department of Oral Maxillofacial Surgery, College of Medicine, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, China.
3
Department of Implantology, The Affiliated Hospital of Qingdao University, Qingdao, China.
4
Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
5
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Abstract

BACKGROUND:

High mobility group AT-hook 2 (HMGA2) and pleomorphic adenoma gene 1(PLAG1) have been demonstrated to be elevated in many malignant tumors. However, the aim of this study was to evaluate HMGA2 and PLAG1 levels in blood as a non-invasive biomarker for oral squamous cell carcinoma (OSCC) diagnosis.

METHODS:

qRT-PCR was performed to measure circulating HMGA2 and PLAG1 levels in OSCC patients (n=43) and matched cancer-free blood control group (n=21). Clinical data of all patients were recorded.

RESULTS:

Circulating HMGA2 and PLAG1 in the 43 OSCC patients was significantly higher than in control group (P<.001, P=.038, respectively). Furthermore, HMGA2 expression in OSCC patients with poor-moderate differentiation was increased compared with well-differentiated group. However, no significant differences in PLAG1 expression were detected when differentiation was considered. In addition, the receiver operating characteristic (ROC) curve analysis for circulating HMGA2 revealed an area under the ROC curve of 0.876 (95% confidence interval, 0.793-0.959; P<.001) with 65.1% sensitivity and 100% specificity in discriminating OSCC from controls at a cutoff value of 14.380, demonstrating significant diagnostic value for OSCC.

CONCLUSION:

Circulating HMGA2 levels are increased in OSCC patients and may potentially serve as a significant index to evaluate OSCC diagnosis.

KEYWORDS:

biomarker; diagnosis; high mobility group A2; oral squamous cell carcinoma; pleomorphic adenoma gene 1

PMID:
28650082
DOI:
10.1111/jop.12609
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center