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Nat Rev Microbiol. 2017 Sep;15(9):517-530. doi: 10.1038/nrmicro.2017.61. Epub 2017 Jun 26.

Pseudomonas predators: understanding and exploiting phage-host interactions.

Author information

1
Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 21, Box 2462, 3001 Heverlee, Belgium.

Abstract

Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant pathogen Pseudomonas syringae. The bacteriophages that infect Pseudomonas spp. mirror the widespread and diverse nature of their hosts. Therefore, Pseudomonas spp. and their phages are an ideal system to study the molecular mechanisms that govern virus-host interactions. Furthermore, phages are principal catalysts of host evolution and diversity, which directly affects the ecological roles of environmental and pathogenic Pseudomonas spp. Understanding these interactions not only provides novel insights into phage biology but also advances the development of phage therapy, phage-derived antimicrobial strategies and innovative biotechnological tools that may be derived from phage-bacteria interactions.

PMID:
28649138
DOI:
10.1038/nrmicro.2017.61
[Indexed for MEDLINE]

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