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Cell Metab. 2017 Jul 5;26(1):39-48. doi: 10.1016/j.cmet.2017.05.016. Epub 2017 Jun 22.

Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells.

Author information

1
Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA 91125, USA.
2
Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA 91125, USA. Electronic address: dchan@caltech.edu.

Abstract

Cancer and stem cells appear to share a common metabolic profile that is characterized by high utilization of glucose through aerobic glycolysis. In the presence of sufficient nutrients, this metabolic strategy provides sufficient cellular ATP while additionally providing important metabolites necessary for the biosynthetic demands of continuous cell proliferation. Recent studies indicate that this metabolic profile is dependent on genes that regulate the fusion and fission of mitochondria. High levels of mitochondrial fission activity are associated with high proliferation and invasiveness in some cancer cells and with self-renewal and resistance to differentiation in some stem cells. These observations reveal new ways in which mitochondria regulate cell physiology, through their effects on metabolism and cell signaling.

KEYWORDS:

cancer; induced pluripotential stem cells; metabolism; mitochondria; mitochondrial dynamics; stem cells

PMID:
28648983
PMCID:
PMC5539982
DOI:
10.1016/j.cmet.2017.05.016
[Indexed for MEDLINE]
Free PMC Article

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