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Trends Mol Med. 2017 Jul;23(7):636-650. doi: 10.1016/j.molmed.2017.05.003.

Exosomes as Reconfigurable Therapeutic Systems.

Author information

1
Swansea University Medical School, Swansea SA2 8PP, UK. Electronic address: r.s.conlan@swansea.ac.uk.
2
Swansea University Medical School, Swansea SA2 8PP, UK; University of Trieste, 34127 Trieste, Italy.
3
International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal.
4
Houston Methodist Research Institute, Houston, TX 77030, USA.
5
International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal. Electronic address: ines.m.pinto@inl.int.

Abstract

Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or 'exosomes'. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases.

PMID:
28648185
PMCID:
PMC5657340
DOI:
10.1016/j.molmed.2017.05.003
[Indexed for MEDLINE]
Free PMC Article

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