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BMB Rep. 2017 Aug;50(8):401-410.

Emerging roles of protein disulfide isomerase in cancer.

Author information

1
Department of Bio and Environmental Technology, Seoul Women's University, Seoul 01797, Korea.

Abstract

The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine-based redox reactions and assist the quality control of client proteins. Recent structural and functional studies have demonstrated that PDI members not only play an essential role in the proteostasis in the ER but also exert diverse effects in numerous human disorders including cancer and neurodegenerative diseases. Increasing evidence suggests that PDI is actively involved in the proliferation, survival, and metastasis of several types of cancer cells. Although the molecular mechanism by which PDI contributes to tumorigenesis and metastasis remains to be understood, PDI is now emerging as a new therapeutic target for cancer treatment. In fact, several attempts have been made to develop PDI inhibitors as anti-cancer drugs. In this review, we discuss the properties and diverse functions of human PDI proteins and focus on recent findings regarding their roles in the state of diseases including cancer and neurodegeneration. [BMB Reports 2017; 50(8): 401-410].

PMID:
28648146
PMCID:
PMC5595169
DOI:
10.5483/bmbrep.2017.50.8.107
[Indexed for MEDLINE]
Free PMC Article

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