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Drug Alcohol Depend. 2017 Sep 1;178:143-149. doi: 10.1016/j.drugalcdep.2017.04.008. Epub 2017 Jun 8.

Body mass index, body dissatisfaction and adolescent smoking initiation.

Author information

1
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK. Electronic address: lh14833@bristol.ac.uk.
2
Musculoskeletal Research Unit, University of Bristol, Learning and Research Building (Level 1), Southmead Hospital, Bristol, BS10 5NB, UK.
3
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.
4
School of Social and Community Medicine, University of Bristol, Bristol, UK.
5
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK; UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, BS8 1TU, United Kingdom.

Abstract

BACKGROUND:

Smoking influences body weight, but there is little evidence as to whether body mass index (BMI) and body dissatisfaction increase smoking initiation in adolescents.

METHODS:

We evaluated the association between measured BMI, body dissatisfaction and latent classes of smoking initiation (never smokers, experimenters, late onset regular smokers, early onset regular smokers) in the Avon Longitudinal Study of Parents and Children. In observational analyses we used BMI (N=3754) and body dissatisfaction at age 10.5 years (N=3349). In Mendelian randomisation (MR) analysis, we used a BMI genetic risk score of 76 single nucleotide polymorphisms (N=4017).

RESULTS:

In females, higher BMI was associated with increased odds of early onset regular smoking (OR: 1.11, 95% CI: 1.04, 1.18) compared to being a never smoker, but not clearly associated with experimenting with smoking (OR: 1.04, 95% CI: 0.99, 1.10) or late onset regular smoking (OR: 1.01, 95% CI: 0.94, 1.09). No clear evidence was found for associations between BMI and smoking initiation classes in males (p-value for sex interaction≤0.001). Body dissatisfaction was associated with increased odds of late-onset regular smoking (OR: 1.71, 95% CI: 1.32, 1.99) in males and females combined (P-value for sex interaction=0.32). There was no clear evidence for an association between the BMI genetic risk score and smoking latent classes in males or females but estimates were imprecise.

CONCLUSIONS:

BMI in females and body dissatisfaction in males and females are associated with increased odds of smoking initiation, highlighting these as potentially important factors for consideration in smoking prevention strategies.

KEYWORDS:

ALSPAC; Body dissatisfaction; Body mass index; Mendelian randomization; Tobacco

PMID:
28647682
PMCID:
PMC5558147
DOI:
10.1016/j.drugalcdep.2017.04.008
[Indexed for MEDLINE]
Free PMC Article

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