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Behav Brain Res. 2017 Aug 30;333:192-202. doi: 10.1016/j.bbr.2017.06.030. Epub 2017 Jun 21.

Testing the physiological plausibility of conflicting psychological models of response inhibition: A forward inference fMRI study.

Author information

1
Université de Lyon, F-69622, Lyon, France; Université Lyon 1, Villeurbanne, France; INSERM, U1028, Lyon Neuroscience Research Center, Lyon, F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Lyon, F-69000, France; Centre de Neuroscience Cognitive, Bron, France; Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada.
2
Laboratoire de Neurosciences Cognitives, CNRS UMR 7291 & Aix-Marseille Université, France.
3
Centre IRMf de Marseille, Institut de Neurosciences de la Timone, CNRS UMR7289 & Aix- Marseille Université, France.
4
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
5
Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada.
6
INSERM, U1028, Lyon Neuroscience Research Center, Lyon, F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Lyon, F-69000, France; Centre de Neuroscience Cognitive, Bron, France.
7
Université de Lyon, F-69622, Lyon, France; Université Lyon 1, Villeurbanne, France; INSERM, U1028, Lyon Neuroscience Research Center, Lyon, F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Lyon, F-69000, France; Centre de Neuroscience Cognitive, Bron, France. Electronic address: philippe.boulinguez@univ-lyon1.fr.

Abstract

The neural mechanisms underlying response inhibition and related disorders are unclear and controversial for several reasons. First, it is a major challenge to assess the psychological bases of behaviour, and ultimately brain-behaviour relationships, of a function which is precisely intended to suppress overt measurable behaviours. Second, response inhibition is difficult to disentangle from other parallel processes involved in more general aspects of cognitive control. Consequently, different psychological and anatomo-functional models coexist, which often appear in conflict with each other even though they are not necessarily mutually exclusive. The standard model of response inhibition in go/no-go tasks assumes that inhibitory processes are reactively and selectively triggered by the stimulus that participants must refrain from reacting to. Recent alternative models suggest that action restraint could instead rely on reactive but non-selective mechanisms (all automatic responses are automatically inhibited in uncertain contexts) or on proactive and non-selective mechanisms (a gating function by which reaction to any stimulus is prevented in anticipation of stimulation when the situation is unpredictable). Here, we assessed the physiological plausibility of these different models by testing their respective predictions regarding event-related BOLD modulations (forward inference using fMRI). We set up a single fMRI design which allowed for us to record simultaneously the different possible forms of inhibition while limiting confounds between response inhibition and parallel cognitive processes. We found BOLD dynamics consistent with non-selective models. These results provide new theoretical and methodological lines of inquiry for the study of basic functions involved in behavioural control and related disorders.

KEYWORDS:

Forward inference; Go/no-go; Non-selective inhibition; Proactive control; Reactive control; Selective inhibition

PMID:
28647596
DOI:
10.1016/j.bbr.2017.06.030
[Indexed for MEDLINE]

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