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Arch Pediatr. 2017 Aug;24(8):777-782. doi: 10.1016/j.arcped.2017.05.012. Epub 2017 Jun 21.

[Acute fatty liver of pregnancy and mitochondrial fatty acid oxidation. Consequences for the offspring].

[Article in French]

Author information

1
Service d'hépato-gastroentérologie, hôpital Trousseau, CHRU de Tours, 37044 Tours cedex, France. Electronic address: Anon.Benjamin@gmail.com.
2
Service de pédiatrie, hôpital Clocheville, CHRU de Tours, 37044 Tours cedex, France.
3
Laboratoire de biochimie et biologie moléculaire, hôpital Bretonneau, CHRU de Tours, 37044 Tours cedex, France.
4
Service d'hépato-gastroentérologie, hôpital Trousseau, CHRU de Tours, 37044 Tours cedex, France.

Abstract

Acute fatty liver of pregnancy (AFLP) is a rare liver disease unique to pregnancy that can lead to acute liver failure. The prognosis, initially often fatal for both mother and child, has been improved by prompt delivery. The diagnosis should be highly suspected if the mother presents epigastric pain, nausea and/or vomiting, or polyuria-polydipsia in the third trimester of pregnancy. AFLP has been found associated with a genetic deficiency of fatty acid beta-oxidation, which may cause sudden death in infancy. Consequently, the mother and her newborn should undergo screening for this deficiency.

PMID:
28647472
DOI:
10.1016/j.arcped.2017.05.012
[Indexed for MEDLINE]

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