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Lancet. 2017 Nov 4;390(10107):2099-2109. doi: 10.1016/S0140-6736(17)31450-2. Epub 2017 Jun 21.

An update on Zika virus infection.

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Materno-fetal and Obstetrics Research Unit, Obstetric Service, Department "Femme-Mère-Enfant", University Hospital, Lausanne, Switzerland. Electronic address:
Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Centre Pluridisciplinaire de Diagnostic Prénatal de Martinique, Service de Gynécologie Obstétrique, Maison de la Femme de la Mère et de l'Enfant, Fort de France, Martinique, France; Registre des Malformations des Antilles (REMALAN), Maison de la Femme de la Mère et de l'Enfant, Centre Hospitalier Universitaire de Martinique, Fort de France, Martinique, France.
Blood Systems Research Institute, San Francisco, CA, USA; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA; Cerus Corporation, Concord, CA, USA.
Unit of Emerging Infectious Diseases, Institut Louis Malardé, Tahiti, French Polynesia.


The epidemic history of Zika virus began in 2007, with its emergence in Yap Island in the western Pacific, followed in 2013-14 by a larger epidemic in French Polynesia, south Pacific, where the first severe complications and non-vector-borne transmission of the virus were reported. Zika virus emerged in Brazil in 2015 and was declared a national public health emergency after local researchers and physicians reported an increase in microcephaly cases. In 2016, WHO declared the recent cluster of microcephaly cases and other neurological disorders reported in Brazil a global public health emergency. Similar clusters of microcephaly cases were also observed retrospectively in French Polynesia in 2014. In 2015-16, Zika virus continued its spread to cause outbreaks in the Americas and the Pacific, and the first outbreaks were reported in continental USA, Africa, and southeast Asia. Non-vector-borne transmission was confirmed and Zika virus was established as a cause of severe neurological complications in fetuses, neonates, and adults. This Review focuses on important updates and gaps in the knowledge of Zika virus as of early 2017.

[Indexed for MEDLINE]

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