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J Invest Dermatol. 2017 Jul;137(7):1405-1408. doi: 10.1016/j.jid.2017.01.026.

Olumacostat Glasaretil, a Promising Topical Sebum-Suppressing Agent that Affects All Major Pathogenic Factors of Acne Vulgaris.

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1
Department of Dermatology, Environmental Medicine, Health Theory, Faculty of Human Sciences, University of Osnabrück, Osnabrück, Germany. Electronic address: melnik@t-online.de.

Abstract

Hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme A carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. Topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. Olumacostat glasaretil-mediated sebum suppression may reduce Propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation.

PMID:
28647025
DOI:
10.1016/j.jid.2017.01.026
[Indexed for MEDLINE]
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