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Environ Int. 2017 Sep;106:135-143. doi: 10.1016/j.envint.2017.06.007. Epub 2017 Jun 20.

Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community.

Author information

1
Division of Community Health Investigations, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA. Electronic address: RWorley@cdc.gov.
2
Division of Community Health Investigations, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA.
3
Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, GA, USA.
4
AXYS Analytical, Sidney, British Columbia, Canada.
5
National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA.

Abstract

BACKGROUND:

Per- and polyfluoroalkyl substances (PFAS) are considered chemicals of emerging concern, in part due to their environmental and biological persistence and the potential for widespread human exposure. In 2007, a PFAS manufacturer near Decatur, Alabama notified the United States Environmental Protection Agency (EPA) it had discharged PFAS into a wastewater treatment plant, resulting in environmental contamination and potential exposures to the local community.

OBJECTIVES:

To characterize PFAS exposure over time, the Agency for Toxic Substances and Disease Registry (ATSDR) collected blood and urine samples from local residents.

METHODS:

Eight PFAS were measured in serum in 2010 (n=153). Eleven PFAS were measured in serum, and five PFAS were measured in urine (n=45) from some of the same residents in 2016. Serum concentrations were compared to nationally representative data and change in serum concentration over time was evaluated. Biological half-lives were estimated for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) using a one-compartment pharmacokinetic model.

RESULTS:

In 2010 and 2016, geometric mean PFOA and PFOS serum concentrations were elevated in participants compared to the general U.S.

POPULATION:

In 2016, the geometric mean PFHxS serum concentration was elevated compared to the general U.S.

POPULATION:

Geometric mean serum concentrations of PFOA, PFOS, and perfluorononanoic acid (PFNA) were significantly (p≤0.0001) lower (49%, 53%, and 58%, respectively) in 2016 compared to 2010. Half-lives for PFOA, PFOS, and PFHxS were estimated to be 3.9, 3.3, and 15.5years, respectively. Concentrations of PFOA in serum and urine were highly correlated (r=0.75) in males.

CONCLUSIONS:

Serum concentrations of some PFAS are decreasing in this residentially exposed community, but remain elevated compared to the U.S. general population.

KEYWORDS:

Biomonitoring; Half-life; PFAS; PFOA; PFOS

PMID:
28645013
PMCID:
PMC5673082
DOI:
10.1016/j.envint.2017.06.007
[Indexed for MEDLINE]
Free PMC Article

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