Format

Send to

Choose Destination
Retina. 2018 Jan;38 Suppl 1:S79-S88. doi: 10.1097/IAE.0000000000001728.

ABNORMAL RETINAL REFLECTIVITY TO SHORT-WAVELENGTH LIGHT IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA.

Author information

1
Department of Research and Development, Moorfields Eye Hospital, London, United Kingdom.
2
UCL Institute of Ophthalmology, London, United Kingdom.
3
Department of Ophthalmology, St. Franziskus Hospital, Münster, Germany.
4
The Emmes Corporation, Rockville, Maryland.
5
National Eye Institute, National Institutes of Health, Bethesda, Maryland.
6
Medical Retina Service, Moorfields Eye Hospital, London, United Kingdom.
7
NIHR Biomedical Research Center for Ophthalmology at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
8
Department of Ophthalmology, Faculty of Medicine Health and Life Sciences, Queen's University Belfast, Belfast, United Kingdom.
9
Inherited Eye Disease, Moorfields Eye Hospital, London, United Kingdom.

Abstract

PURPOSE:

Macular telangiectasia Type 2 (MacTel) is a bilateral, progressive, potentially blinding retinal disease characterized by vascular and neurodegenerative signs, including an increased parafoveal reflectivity to blue light. Our aim was to investigate the relationship of this sign with other signs of macular telangiectasia Type 2 in multiple imaging modalities.

METHODS:

Participants were selected from the MacTel Type 2 study, based on a confirmed diagnosis and the availability of images. The extent of signs in blue-light reflectance, fluorescein angiographic, optical coherence tomographic, and single- and dual-wavelength autofluorescence images were analyzed.

RESULTS:

A well-defined abnormality of the perifovea is demonstrated by dual-wavelength autofluorescence and blue-light reflectance in early disease. The agreement in area size of the abnormalities in dual-wavelength autofluorescence and in blue-light reflectance images was excellent: for right eyes: ρ = 0.917 (P < 0.0001, 95% confidence interval 0.855-0.954, n = 46) and for left eyes: ρ = 0.952 (P < 0.0001, 95% confidence interval 0.916-0.973, n = 49). Other changes are less extensive initially and expand later to occupy that area and do not extend beyond it.

CONCLUSION:

Our findings indicate that abnormal metabolic handling of luteal pigment and physical changes giving rise to increased reflectance are widespread in the macula throughout the natural history of the disease, precede other changes, and are relevant to early diagnosis.

PMID:
28644304
PMCID:
PMC5726908
[Available on 2019-01-01]
DOI:
10.1097/IAE.0000000000001728
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center