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Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11399-11403. doi: 10.1002/anie.201704904. Epub 2017 Jul 5.

Ceria-Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment.

Soh M1,2, Kang DW3,4, Jeong HG3,4, Kim D1,2, Kim DY3,4, Yang W3,4, Song C1,2, Baik S1,2, Choi IY3,4, Ki SK3,4, Kwon HJ1,2, Kim T1,2, Kim CK3,5, Lee SH3,4, Hyeon T1,2.

Author information

1
Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.
2
School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.
3
Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
4
Department of Neurology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
5
Department of Neurology, Korea University Guro Hospital and Korea University College of Medicine, Seoul, 08308, Republic of Korea.

Abstract

The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+ , play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2- and . OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria-zirconia nanoparticles (CZ NPs) that possess a higher Ce3+ /Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7 Zr0.3 O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.

KEYWORDS:

ceria-zirconia nanoparticles; inflammation; reactive oxygen species; sepsis; therapeutic nanomedicine

PMID:
28643857
DOI:
10.1002/anie.201704904
[Indexed for MEDLINE]

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