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J Int Med Res. 2017 Dec;45(6):1901-1929. doi: 10.1177/0300060516675504. Epub 2017 Jan 12.

Coronary microvascular dysfunction in diabetes mellitus.

Author information

1
1 Department for Heart and Vascular Diseases, Clinic of Internal Medicine, Osijek University Hospital, Osijek, Croatia.
2
2 Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, Croatia.
3
3 Department of Internal Medicine, Faculty of Medicine, University of Osijek, Osijek, Croatia.
4
4 Department of Endocrinology, Clinic of Internal Medicine, Osijek University Hospital, Osijek, Croatia.
5
5 Department of Diagnostic and Interventional Radiology, Osijek University Hospital, Osijek, Croatia.

Abstract

The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives.

KEYWORDS:

Diabetes mellitus; arachidonic acid metabolites; artery; cardiomyopathy; coronary microvascular dysfunction; endothelial dysfunction; microcirculation; nitric oxide

PMID:
28643578
PMCID:
PMC5805190
DOI:
10.1177/0300060516675504
[Indexed for MEDLINE]
Free PMC Article

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