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Diabetes Obes Metab. 2018 Jan;20(1):94-102. doi: 10.1111/dom.13042. Epub 2017 Aug 2.

Bimagrumab improves body composition and insulin sensitivity in insulin-resistant individuals.

Author information

1
Diabetes Research Institute (OSR-DRI), San Raffaele Vita-Salute University, Milan, Italy.
2
Novartis Institutes for Biomedical Research, Basel, Switzerland.
3
ProSciento Inc., Chula Vista, California.
4
Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
5
Departments of Psychiatry and Radiology, University of California, San Diego, California.
6
Novartis Healthcare Private Ltd, Hyderabad, India.

Abstract

AIM:

To test the hypothesis that an improving body composition in insulin-resistant individuals could enhance insulin sensitivity.

METHODS:

A total of 16 people with a mean body mass index of 29.3 kg/m2 and insulin resistance, received a single dose of bimagrumab or placebo and were assessed at week 10 for insulin sensitivity, using a hyperinsulinaemic-euglycaemic clamp and an intravenous glucose tolerance test (IVGTT), and for body composition using dual energy X-ray absorptiometry and positron-emission tomography.

RESULTS:

Bimagrumab increased lean mass by 2.7% (P < .05) and reduced fat mass by 7.9% (P = .011) at week 10 compared with placebo, and had a neutral effect on body weight. Bimagrumab reduced glycated haemoglobin by 0.21% at week 18 (P < .001) and improved insulin sensitivity by ~20% (according to the clamp) to ~40% (according to the IVGTT).

CONCLUSION:

Taking the observed changes together, and given that these occurred without accompanying dietary intervention and without any prescribed regular physical exercise, bimagrumab may offer a novel approach for the treatment of the metabolic complications of obesity.

KEYWORDS:

HbA1c; activin receptor II; bimagrumab; body composition; insulin resistance; obesity

PMID:
28643356
DOI:
10.1111/dom.13042
[Indexed for MEDLINE]

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