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Arch Virol. 2017 Oct;162(10):3007-3015. doi: 10.1007/s00705-017-3447-5. Epub 2017 Jun 22.

Molecular characteristics and prevalence of small ruminant lentiviruses in goats in Japan.

Author information

1
Faculty of Agriculture, Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
2
Faculty of Engineering, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Nakagami District, Okinawa, 903-0129, Japan.
3
Department of Bioproduction Science, Ishikawa Prefectural University, Nonoichi, Ishikawa, 921-8836, Japan.
4
Faculty of Agriculture, Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. tomatsu@cc.tuat.ac.jp.

Abstract

Small ruminant lentiviruses (SRLVs), which comprise caprine arthritis-encephalitis virus (CAEV) and maedi-visna virus (MVV), are prevalent in goats and sheep worldwide, including in Japan. However, little is known about the molecular characteristics of goat lentiviruses in Japan. In this study, a molecular and phylogenetic analysis of the long gag region was performed. The phylogenic tree demonstrated that all samples belonged to SRLV subtype B1. Two clusters were identified, with one cluster distinct from previously reported strains of subtype B1. In addition, several alterations in the amino acid sequence were detected in immunodominant epitopes of the gag region. To gain a deeper understanding of the genetic diversity of SRLVs in Japan, it will be necessary to increase the sample size and conduct a broader survey. The present report is important for establishing baseline information on the prevalence of SRLV in Japan and providing data to develop a new, more sensitive diagnostic test for effective control of SRLV.

PMID:
28642977
DOI:
10.1007/s00705-017-3447-5
[Indexed for MEDLINE]

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