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Nat Rev Cancer. 2017 Jun 23;17(7):399-414. doi: 10.1038/nrc.2017.41.

Imaging of anticancer drug action in single cells.

Author information

1
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
2
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Imaging is widely used in anticancer drug development, typically for whole-body tracking of labelled drugs to different organs or to assess drug efficacy through volumetric measurements. However, increasing attention has been drawn to pharmacology at the single-cell level. Diverse cell types, including cancer-associated immune cells, physicochemical features of the tumour microenvironment and heterogeneous cell behaviour all affect drug delivery, response and resistance. This Review summarizes developments in the imaging of in vivo anticancer drug action, with a focus on microscopy approaches at the single-cell level and translational lessons for the clinic.

PMID:
28642603
DOI:
10.1038/nrc.2017.41
[Indexed for MEDLINE]

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