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Neuron. 2017 Jun 21;94(6):1043-1046. doi: 10.1016/j.neuron.2017.06.016.

Live or Die? Depends on Who You Are.

Author information

1
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
2
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: cam4@columbia.edu.

Abstract

In this issue of Neuron, Welsbie et al. (2017) and Norsworthy et al. (2017) implicate the transcription factor Sox11 as a key player after optic nerve injury-in DLK signaling of RGC cell death, and in RGC regeneration and survival but only in certain RGCs.

KEYWORDS:

DLK; PTEN; axon regeneration; cell death; ceramide; retinal ganglion cell

PMID:
28641102
DOI:
10.1016/j.neuron.2017.06.016
[Indexed for MEDLINE]
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