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Org Biomol Chem. 2017 Jul 5;15(26):5571-5578. doi: 10.1039/c7ob01266g.

Diastereoselective [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2: syntheses of CF2H-containing spirooxindoles.

Author information

1
Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. hanwy@zmc.edu.cn yzchen@zmc.edu.cn.

Abstract

An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2 for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CF2H group and three contiguous stereogenic centers in up to 84% yield and 99 : 1 trans/cis.

PMID:
28639676
DOI:
10.1039/c7ob01266g

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