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Cell Mol Life Sci. 2017 Nov;74(22):4097-4120. doi: 10.1007/s00018-017-2571-4. Epub 2017 Jun 21.

Nuclear receptors in neural stem/progenitor cell homeostasis.

Author information

1
Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou Str, 115 27, Athens, Greece.
2
Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou Str, 115 27, Athens, Greece. ppolitis@bioacademy.gr.

Abstract

In the central nervous system, embryonic and adult neural stem/progenitor cells (NSCs) generate the enormous variety and huge numbers of neuronal and glial cells that provide structural and functional support in the brain and spinal cord. Over the last decades, nuclear receptors and their natural ligands have emerged as critical regulators of NSC homeostasis during embryonic development and adult life. Furthermore, substantial progress has been achieved towards elucidating the molecular mechanisms of nuclear receptors action in proliferative and differentiation capacities of NSCs. Aberrant expression or function of nuclear receptors in NSCs also contributes to the pathogenesis of various nervous system diseases. Here, we review recent advances in our understanding of the regulatory roles of steroid, non-steroid, and orphan nuclear receptors in NSC fate decisions. These studies establish nuclear receptors as key therapeutic targets in brain diseases.

KEYWORDS:

Agonists/antagonists; Astrogliogenesis; Brain development; Drug targets; Glucocorticoid; Neurogenesis; Neurological diseases; Retinoic acid

PMID:
28638936
DOI:
10.1007/s00018-017-2571-4
[Indexed for MEDLINE]

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