Format

Send to

Choose Destination
J Clin Exp Dent. 2017 Jun 1;9(6):e729-e732. doi: 10.4317/jced.53679. eCollection 2017 Jun.

Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis.

Author information

1
Associated Professor, Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
2
Associated professor, Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
3
Postgraduate Student, Dep of Oral Medicine, School of Dentistry, Zahedan University of Medical Science, Zahedan, Iran.

Abstract

BACKGROUND:

Recently alternative therapies such as the use of diode laser therapy have been introduced for recurrent herpes labial infection. The aim of this study was to evaluate the effectiveness of diode laser for treatment of recurrent herpes labialis.

MATERIAL AND METHODS:

This was single-blind randomized clinical trial to evaluate the efficacy of diode laser for the treatment of recurrent herpes labial. In total, 60 patients whit recurrent herpes simplex labialis were selected and randomly divided in to three groups. 20 patients received treatment whit diode laser (at a wavelength of 870 nm, energy density 4.5 j/cm2), 20 patients were treated with acyclovir cream 5%, 20 patients received treatment with laser-off (placebo). The end point was lesions crusting. Data analyzed by Tukey HSD Test and One-way ANOVA (at a significance level of 0.05) in SPSS-20 software.

RESULTS:

The mean length of recovery time (day) in the laser, off laser, and acyclovir groups was 2.20±0.41, 4.30±1.03, and 3.4±1.142, respectively. There is a significant difference between three groups in this regard (P<0.0001). The mean duration of pain (day) was 1.35±0.74, 2.65±1.27, and 2.30±0.92 for laser, off laser, and acyclovir groups, respectively (P<0.0001).

CONCLUSIONS:

Treatment with diode laser reduced the length of recovery time and pain severity faster than treatment with acyclovir cream. Key words:Recurrent herpes labial, Acyclovir, Low level laser therapy.

Conflict of interest statement

Conflict of interest statement:There was not conflict of interest of financial benefit to any parties involved in this study.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center