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Front Immunol. 2017 Jun 7;8:496. doi: 10.3389/fimmu.2017.00496. eCollection 2017.

Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia.

Author information

1
Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
2
Third Faculty of Medicine, Department of Molecular Biology and Cell Pathology, Charles University, Prague, Czechia.
3
Department for Hematopoietic Cell Transplantation, University Hospital Augsburg, Munich, Germany.
4
Department for Hematopoietic Cell Transplantation, Internal Medicine III, Hospital of the University of Munich, Munich, Germany.
5
Department of Hematology-Oncology Immunology Infectious Diseases, Klinikum München-Schwabing, Munich, Germany.

Abstract

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

KEYWORDS:

LAA specific T cells; allogenic natural killer cells; animal models; donor lymphocyte infusion; graft-versus-leukemia effect; invariant natural killer T cells (i)NKT; leukaemia associated antigens (LAA); leukaemia derived dendritic cells; leukaemia specific antigens

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