Format

Send to

Choose Destination
J Oral Sci. 2017;59(2):167-171. doi: 10.2334/josnusd.16-0847.

Neural mechanisms of nociception during orthodontic treatment.

Author information

1
Department of Pharmacology, Nihon University School of Dentistry.
2
Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry.
3
Molecular Imaging Research Center, RIKEN.
4
Department of Orthodontics, Nihon University School of Dentistry.

Abstract

Orthodontic tooth movement is accompanied by inflammatory responses in the periodontal ligament. Chemical mediators such as interleukin-1β have key roles in nociception around teeth. Such nociceptive inputs to the periodontal ligament continue for several days and potentially induce plastic changes in higher brain regions, including the cerebral cortex. This review summarizes research on orthodontic treatment-induced modulation of neural activities in the central nervous system. Furthermore, we describe our recent findings on the spatiotemporal effects of orthodontic treatment in the somatosensory and insular cortices.

KEYWORDS:

central nervous system; experimental tooth movement; inflammation; pain; periodontal ligament

PMID:
28637973
DOI:
10.2334/josnusd.16-0847
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center