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Br J Nutr. 2017 Jun;117(11):1596-1602. doi: 10.1017/S0007114517001465. Epub 2017 Jun 22.

Evaluation of urinary resveratrol as a biomarker of dietary resveratrol intake in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

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1Unit of Nutrition and Cancer,Epidemiology Research Program Catalan Institute of Oncology,Bellvitge Biomedical Research Institute (IDIBELL),08908 Barcelona,Spain.
2Section of Nutrition and Metabolism,International Agency for Research on Cancer (IARC-WHO),69372 Lyon,France.
3Centre de recherche en épidémiologie et santé des populations (CESP),Institut National de la Santé et de la Recherche Médicale (INSERM),Université de Versailles Saint-Quentin-en-Yvelines (UVSQ),Université Paris-Sud,Université Paris-Saclay,94805 Villejuif,France.
5Division of Cancer Epidemiology,German Cancer Research Center,69120 Heidelberg,Germany.
6Department of Epidemiology,German Institute of Human Nutrition Potsdam-Rehbruecke,14558 Nuthetal,Germany.
7Hellenic Health Foundation,GR-115 27, Athens,Greece.
11Cancer Risk Factors and Life-Style Epidemiology Unit,Cancer Research and Prevention Institute (ISPO),50141 Florence,Italy.
12Environmental Epidemiology Unit,Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori,20133 Milan,Italy.
13Dipartimento di Medicina Clinica e Chirurgia,Federico II University,80131 Naples,Italy.
14Cancer Registry and Histopathology Unit,'Civic M.P. Arezzo' Hospital,97100 Ragusa,Italy.
15Unit of Epidemiology,Regional Health Service ASL TO3,Grugliasco (TO),10093 Turin,Italy.


In vitro studies have shown several beneficial properties of resveratrol. Epidemiological evidence is still scarce, probably because of the difficulty in estimating resveratrol exposure accurately. The current study aimed to assess the relationships between acute and habitual dietary resveratrol and wine intake and urinary resveratrol excretion in a European population. A stratified random subsample of 475 men and women from four countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study, who had provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day, were included. Acute and habitual dietary data were collected using standardised 24-HDR software and a validated country-specific dietary questionnaire, respectively. Phenol-Explorer was used to estimate the intake of resveratrol and other stilbenes. Urinary resveratrol was analysed using tandem MS. Spearman's correlation coefficients between estimated dietary intakes of resveratrol and other stilbenes and consumption of wine, their main food source, were very high (r>0·9) when measured using dietary questionnaires and were slightly lower with 24-HDR (r>0·8). Partial Spearman's correlations between urinary resveratrol excretion and intake of resveratrol, total stilbenes or wine were found to be higher when using the 24-HDR (R 2 partial approximately 0·6) than when using the dietary questionnaires (R 2 partial approximately 0·5). Moderate to high correlations between dietary resveratrol, total stilbenes and wine, and urinary resveratrol concentrations were observed. These support the earlier findings that 24-h urinary resveratrol is an effective biomarker of both resveratrol and wine intakes. These correlations also support the validity of the estimation of resveratrol intake using the dietary questionnaire and Phenol-Explorer.


24-HDR 24-h dietary recall; DQ dietary questionnaire; Biomarkers; Intakes; Resveratrol; Urine; Wine

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